^(18)F-FDG符合线路SPECT/CT显像在诊断肺癌纵隔淋巴结转移中的价值  

^(18)F-FDG coincidence SPECT/CT imaging in the diagnosis of mediastinal lymph node metastasis of lung cancer

作　　者：陈飞[1] 马宁帅[1] 何宗喜[1] 李素平[1] 谢建平[1] 张涛[1] 游金辉[1] 

机构地区：[1]川北医学院附属医院核医学科,四川南充637000

出　　处：《现代肿瘤医学》2016年第3期413-416,共4页Journal of Modern Oncology

基　　金：四川省南充市市级应用技术研究与开发资金项目(编号:14A0041)

摘　　要：目的:探讨18氟-脱氧葡萄糖(^(18)F-FDG)符合线路SPECT/CT显像在诊断肺癌纵隔淋巴结转移中价值。方法:回顾性研究我院2013年1月至2014年11月确诊为肺癌的100例患者,肿瘤分型鳞癌患者14例、腺癌患者70例、大细胞癌5例及其他类型的15例,运用^(18)F-FDG符合线路对患者的纵隔淋巴结的诊断结果分类,包括阴性组70例、阳性组30例。参照肺癌术后的病理学诊断标准,评价^(18)F-FDG符合线路SPECT/CT显像在肺癌中的诊断价值,分析假阴性和假阳性患者各项危险因素指标之间的差异性。结果:^(18)F-FDG符合线路SPECT/CT显像在诊断肺癌纵隔淋巴结转移中具有较高的特异性、敏感性,其阳性预测值为78%,阴性预测值为83%,假阴性组的原发灶T/N比值(7.21±3.52)、淋巴结短径(6.58±2.12)mm,小于真阳性组[(9.58±4.53)、(10.02±2.89)mm];假阳性组伴有局限性肺炎(n=8)、慢性支气管炎或肺气肿(n=13)的多于真阳性组(n=2、4)。结论:^(18)F-FDG符合线路SPECT/CT显像是诊断肺癌纵隔淋巴结转移的重要手段,假阴性的发生与原发灶T/N比值、淋巴结短径短小具有相关性,假阳性淋巴结与局限性肺炎、慢支炎肺气肿具有相关性。Objective：To investigate the value of ^18F-deoxyglucose（^18F-FDG） for coincidence SPECT/CT imaging in the diagnosis of mediastinal lymph node metastasis of lung cancer.Methods：Lung cancer patients 100 cases were retrospectively studied.Based on the patient＇s tumor type,including 14 patients with squamous cell carcinoma,adenocarcinoma 70 patients,large cell carcinoma 5 patients,other types of 15.To use ^18F-FDG in line for diagnosis of patients with mediastinal lymph node line classification,including 70 cases of negative group,30 cases of positive group,and evaluate ^18F-FDG coincidence with SPECT/CT imaging.Results：^18F-FDG coincidence SPECT/CT imaging with high specificity and sensitivity in the diagnosis of mediastinal lymph node metastasis.The positive predictive value was 78%,negative predictive value 83% false-negative primary group stove T/N ratio（7.21±3.52）,short diameter （6.58±2.12）mm less than true-positive lymph node group[（9.58±4.53）,（10.02±2.89）mm].False-positive group,the limitations of pneumonia（n=8）,emphysema or chronic bronchitis（n=13） were higher than the true positive group（n=2,4）.Conclusion：^18F-FDG coincidence SPECT/CT imaging is an important mean of diagnosis for mediastinal lymph node metastasis.

关 键 词：^18F-FDG符合线路 肺癌 纵隔淋巴结转移 SPECT/CT显像 

分 类 号：R734.2[医药卫生—肿瘤]