宫颈癌根治性放疗后下肢深部静脉血栓形成的临床分析  

The clinical analysis of deep vein thrombosis of lower limb after radical radiotherapy in cervical cancer

作　　者：热伊拉.麦买提伊敏 开丽曼.阿不都巴热 杨杰[1] 张泽高[1] 

机构地区：[1]新疆维吾尔自治区人民医院放疗二科,新疆乌鲁木齐830001

出　　处：《现代肿瘤医学》2016年第3期454-457,共4页Journal of Modern Oncology

基　　金：新疆维吾尔自治区自然科技基金(编号:2014211A061)

摘　　要：目的:探讨宫颈癌放疗后下肢深静脉血栓的发生率、发生时间及影响因素。方法:回顾性分析2008-2011年在我院行体外照射加^(252)Cf中子腔内根治性放疗的宫颈癌病例,共516例。分析下肢深静脉的发生率和发生中位时间,单因素分析同步化疗、临床分期、年龄、血清D-二聚体与下肢深静脉血栓形成的关系以及治疗效果。结果:共发生下肢静脉血栓12例,发生率为2.33%。下肢深静脉血栓的中位年龄为45岁。放疗后至确诊发生严重深部静脉血栓的中位时间为6个月。单因素分析结果显示年龄和临床分期在有血栓和无血栓组间差异无统计学意义,而是否行同步化疗差异显著(P=0.022)。结论:宫颈癌放疗后可能出现有明显临床症状的下肢深静脉血栓,血栓的发生与患者的年龄和临床分期无明显相关,但同步化疗可能增加血栓的发生。Objective：To investigate the rate of deep venous thrombosis,the occurrence time in cervical cancer after radiotherapy and its risk factors. Methods： Data of 516 cases experienced external irradiation and Californium - 252 neutron brachytherapy between 2008 and 2011 were analyzed for the rate of deep venous thrombosis and the occurrence time. Univariate analysis was conducted for the correlation of deep venous thrombosis with clinical stage, age,serum D - dimer and chemoradiation, as well as the treatment efficacy of deep venous thrombosis. Results ： Twelve ca- ses were diagnosed as deep venous thrombosis and the incidence was 2.33%. The median age was 45 years old. The median time of diagnosis with deep vein thrombosis after radiotherapy was 6 months. Univariate analysis showed that deep vein thrombosis had significant correlation with chemoradiation（P = 0. 022） ,and no significant correlation with age or clinical stage. Conclusion：Deep venous thrombosis may occur after radiotherapy in cervical cancer, which has no obvious relation with age and the clinical stage, but chemoradiation may increase its incidence.

关 键 词：子宫颈肿瘤 放射疗法 下肢深部静脉血栓 并发症 

分 类 号：R737.33[医药卫生—肿瘤]