HPV感染对口咽癌无病生存期影响的Meta分析  

Meta-analysis of Association Between HPV Infection and Disease-free Survival of Oropharyngeal Cancer Patients

作　　者：陈法[1] 何保昌[1] 黄江峰[1] 刘芳萍[1] 林李嵩[2] 郑晓燕[2] 蔡琳[1] 

机构地区：[1]福建医科大学公共卫生学院流行病与卫生统计学系,福州350108 [2]福建医科大学附属第一医院口腔颌面外科,福州350004

出　　处：《肿瘤防治研究》2016年第1期30-34,共5页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金(30771845;81172766);头颈部肿瘤遗传因素与环境因素的国际多中心研究项目(2014B008);福建省教育厅科研目(JA13141)

摘　　要：目的综合评价人乳头状瘤病毒（HPV）感染与口咽癌无病生存期（disease-free survival,DFS）的关联。方法检索中国知网、维普、万方、Pub Med等数据库,全面收集研究HPV感染与口咽癌无病生存期关系的文献,设定纳入和排除标准,评价文献质量,检验异质性,计算合并风险比（HR）及其95%可信区间（95%CI）,评估发表偏倚。结果纳入文献16篇,口咽癌病例共2 512例,其中HPV阳性1 210例,HPV阳性率48.17%,HPV阴性1 302例。与HPV阴性相比,HPV感染的口咽癌病例复发或转移风险较低（合并HR：0.371,95%CI：0.231~0.511）,其中HPV-16型感染对口咽癌DFS的合并HR为0.248,95%CI：0.132~0.365;HPV阳性且p16蛋白表达对口咽癌DFS有保护作用（合并HR：0.281,95%CI：0.137~0.424）。结论 HPV感染对口咽癌无病生存期可能有保护作用。Objective To evaluate the relationship between HPV infection and the disease-free survival（DFS） of oropharyngeal cancer（OPC） patients.Methods Databases including CNKI,VIP,Wanfang data and Pub Med were searched for relevant studies on HPV infection and OPC prognosis.According to the inclusion and exclusion criteria,these studies were screened,and the merging relative risk ratio（HR） and 95% confidence interval（95%CI） were calculated.Results A total of sixteen qualified articles were involved,including 2 512 OPC patients（1 210 cases of HPV positive and 1 302 cases of HPV negative）.HPV positive rate was 48.17%.Compared with HPV negative patients,HPV infection had a protective effect on the recurrence or metastasis of OPC（HR：0.371,95%CI：0.231-0.511）;the single type of HPV-16 infection had lower risk of DFS of OPC（HR：0.248,95%CI：0.132-0.365）.Simultaneous HPV16 positive and p16 overexpression was inversely related with the low risk of recurrence or metastasis of OPC（HR：0.281,95%CI：0.137-0.424）.Conclusion HPV infection may be a benefi cial factor for the DFS of oropharyngeal cancer patients.

关 键 词：口咽癌 人乳头状瘤病毒 无病生存期 META分析 

分 类 号：R739.63[医药卫生—肿瘤]