中枢神经系统血管母细胞瘤临床病理特征  

Clinicopatholigical analysis of central nervous system hemangioblastoma

作　　者：于涓瀚[1] 宋敏[1] 邱雪杉[1] 王恩华[1] 

机构地区：[1]中国医科大学基础医学院病理教研室中国医科大学附属第一医院病理科,辽宁沈阳110001

出　　处：《现代肿瘤医学》2016年第4期545-548,共4页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(编号:81301837)

摘　　要：目的:探讨中枢神经系统血管母细胞瘤临床病理特征。方法:回顾性分析59例中枢神经系统血管母细胞瘤病例,分析其临床特点及组织形态学和免疫组织化学特征。结果:59例血管母细胞瘤病例中,男∶女为1.68∶1,平均年龄为45.5岁。52例(88.1%)发生于小脑。组织学特点:肿瘤与正常脑组织间界限清楚,由富于脂质的泡沫状间质细胞及丰富的血管构成。免疫组化结果显示:肿瘤的间质细胞对Vimentin、NSE及Inhibin-a等多呈阳性表达,而对CK、EMA、GFAP等多呈阴性表达。结论:血管母细胞瘤是少见的中枢神经系统肿瘤,组织形态多样,应注意与中枢神经系统其他肿瘤及转移性肾透明细胞癌等鉴别。Objective： To analyze the clinicopathological features of central nervous system hemangioblastoma（ HB）. Methods： Clinicopathological features and the immunophenotypes of 59 HB patients were retrospectively analyzed. Results： There were 37 males and 22 females,the average age was 45. 5 years old. The tumor most frequently affects the cerebellum（ 52 cases,88. 1%）. HB was well-circumscribed and characterized histologically by two main components： Vacuolated stromal cells and abundant vascular cells. Immunohistochemical results showed that the stromal cells were positive for Vimentin,NSE,and Inhibin-a,but negative for CK,EMA,and GFAP. Conclusion： HB is a rare tumor of central nervous system with various histopathological features,which should be distinguished from renal carcinoma and other tumors of central nervous system.

关 键 词：血管母细胞瘤 病理特征 免疫组织化学 鉴别诊断 

分 类 号：R739.4[医药卫生—肿瘤]