血清中microRNA-210表达水平对胃癌的诊断价值  

The diagnostic value of serum microRNA-210 in gastric cancer

作　　者：齐京鹏 史阿娉 丰帆[3] 仁贵 张洪伟[3] 

机构地区：[1]西安医学院第一附属医院肿瘤科,陕西西安710077 [2]西电集团医院超声科,陕西西安710077 [3]第四军医大学西京消化病医院消化外科,陕西西安710032

出　　处：《现代肿瘤医学》2016年第4期597-599,共3页Journal of Modern Oncology

基　　金：国家自然科学基金青年基金项目(编号:81301804)

摘　　要：目的:microRNA-210(miRNA-210)在胃癌组织中表达上调,血液中也能检测到miRNA-210的表达,本研究旨在探索血清中miRNA-210的表达水平对胃癌的诊断价值。方法:选取100例胃癌患者和100例健康成人,血清中miR-210的表达检测采用实时定量PCR法。评估循环血中miR-210用于胃癌诊断的敏感性、特异性,分析血清中miR-210对不同分期胃癌的诊断价值。结果:胃癌患者血清中miR-210较健康对照组显著升高,血清中miR-210对胃癌诊断的敏感性和特异性分别为85.6%和82.4%,血清miR-210对胃癌Ⅰ到Ⅳ期的阳性预测值分别为89.95%,90.31%,90.45%和91.21%。结论:血清miR-210可作为胃癌诊断的生物标志物。Objective： To study microRNA-210（ miRNA-210） expression in gastric cancer（ GC）. Methods：100 GC patients and 100 healthy controls were recruited. miR-210 levels in serum was quantified using quantitative real-time PCR. The sensitivity and specificity of serum miR-210,were determined. Results： The levels of miR-210 in serum increased significantly in GC patients comparing to healthy controls. The sensitivity and specificity of miR-210 in serum were 85. 6%,82. 4%. The positive prediction rates of circulating miR-210 in GC stages I to IV were 89. 95%,90. 31%,90. 45% and 91. 21%. Conclusion： Serum miR-210 can serve as a good biomarker for GC diagnosis.

关 键 词：血清 miRNA-210 胃癌 肿瘤标志物 

分 类 号：R735.2[医药卫生—肿瘤]