乳腺癌的遗传易感性  

The research progress of breast cancer genetic predisposition

作　　者：徐明贵[1,2] 陈梦云[2] 黄鹤群[2] 许奕荟 许静凯 张博[1,2] 

机构地区：[1]安徽医科大学第二附属医院肿瘤中心,安徽合肥230601 [2]安徽医科大学生命科学学院,安徽合肥230023

出　　处：《现代肿瘤医学》2016年第4期668-671,共4页Journal of Modern Oncology

基　　金：国家自然科学基金青年科学基金项目(编号:81301771)

摘　　要：乳腺癌作为全球女性发病率最高的恶性肿瘤,近年来对其发生发展的研究日益增多及深入。众多研究者运用全基因组关联分析(genome-wide association study,GWAS)以及测序技术,发现并鉴定出了多个乳腺癌的易感基因及位点,为乳腺癌发病机制的研究提供了重要的线索。为了发现更多的乳腺癌易感基因及位点,研究者不再局限于单一的研究方法,而是联合运用多种研究方法来进行乳腺癌的遗传易感性研究。本文详细介绍这些研究方法及应用在乳腺癌易感基因研究中的进展。Breast cancer as the world＇s highest incidence of female malignant tumor in recent years,research on its occurrence and development increased deeply. Many researchers used genome-wide association analysis（ genome-wide association study,GWAS） and sequencing technologies,to find and identify the number of breast cancer susceptibility genes / locus,for research provides an important direction to the pathogenesis of breast cancer. The present study is not limited to a single research method,but using a variety of research methods for studying the genetic susceptibility to breast cancer,in order to further study the development mechanism of breast cancer,people start to find the function of these susceptibility genes with the follow-up studies. This article introduces detailed research method and its application progress in the study of breast cancer hereditary susceptibility.

关 键 词：乳腺癌 遗传易感性 全基因组外显子测序 外显子测序 

分 类 号：R737.9[医药卫生—肿瘤]