头面部恶性肿瘤^(18)F-FDG符合线路/CT显像T/N比值分析  

The target/no target ratio analysis of ^(18)F-FDG uptaking in head and neck malignancy by SPECT/CT coincidence imaging

作　　者：李楠[1] 毛夕保[1] 丁晨旻 包文骏[1] 范晶[1] 薛宁娟[1] 

机构地区：[1]常州市第四人民医院苏州大学附属常州肿瘤医院核医学科,213001

出　　处：《天津医药》2016年第1期98-101,共4页Tianjin Medical Journal

摘　　要：目的探讨头面部恶性肿瘤治疗后18F-脱氧葡萄糖(FDG)符合线路/CT显像中18F-FDG摄取程度的影响因素。方法对32例经手术治疗、放疗或放疗加化疗后头面部恶性肿瘤患者18F-FDG符合线路/CT显像图进行分析,计算靶/非靶摄取(T/N)比值,并按性别、年龄、空腹血糖浓度、原发病灶直径、肿瘤部位、肿瘤病理类型、肿瘤细胞分化程度、治疗方式进行组间比较。结果年龄>70岁组T/N比值大于41~50岁和51~60岁组(均P<0.05);病灶直径<2 cm组T/N比值低于直径2~5 cm及直径>5 cm组(均P<0.05);原发肿瘤细胞低分化小于未分化组(P<0.05)。其余分析指标组间T/N比值差异均无统计学意义(均P>0.05)。多重线性回归分析结果示,T/N比值(Y)与患者年龄(X2)、原发病灶直径(X4)和肿瘤细胞分化程度(X9)相关:=-4.389 25+0.053 03 X2+1.617 86 X4+0.718 35 X9。结论患者年龄>70岁、原发灶直径≥2 cm、肿瘤细胞未分化的头面部恶性肿瘤治疗后残余或复发可能性较大,特别应重视这部分患者的随访诊疗。Objective To investigate the influencing factors of 18F-FDG uptaking in head and neck malignancy by SPECT/CT coincidence imaging. Methods 18F-FDG SPECT/CT coincidence imaging was performed in 32 patients with head and neck malignancy after surgery, radiotherapy or radiotherapy ＋ chemotherapy. The radio of target/no target （T/N） was calculated. The gender, age, fasting blood glucose level, size of tumor, location of tumor, pathological classification, de- gree of cell differentiation and treatment modalities were analyzed between groups. Results The single-factor analysis of variance showed that the T/N value was significantly higher in 〉70 yeas old, group than that of 41-50 yeas old group and 51-60 yeas old group （P 〈 0.05）. The T/N value was significantly lower in tumor size 〈2 cm group than that of 2-5 em group and 〉 5 cm group （P 〈 0.05）. And it was lower in poor differentiated tumor group than that of. undifferentiated tumor group （/9 〈 0.05）. There were no significant differences in T/N values between other indicator groups （P 〉 0.05）. The multiple linear regression analysis showed that ~SF-FDG uptaking in head and neck malignancy （T/N=Y） was related to the age of patients （X2）, the diameter of tumor （X4） and the degree of cell differentiation （X9）：Y=-4.389 25＋0.053 03 X2＋1.617 86 X4＋ 0.718 35 X9. Conclusion Tumor recurrence is more likely to occur in patients with age 〉70 years old, the diameter of tumor≥2 cm, and the anaplastic head and neck malignancy.We should pay much attention to the diagnosis and follow-up for these pa- tients.

关 键 词：头颈部肿瘤 肿瘤复发 局部 放射性核素体层摄影术 单光子发射型计算机 脱氧葡萄糖 符合线路 

分 类 号：R739.81[医药卫生—肿瘤]