PTEN蛋白表达与乳腺癌患者临床病理学特征相关性的Meta分析  

Clinicopathological significance of PTEN protein expression in breast cancer:a Meta-analysis

作　　者：方程[1] 龙行华[1] 

机构地区：[1]武汉大学中南医院检验科,武汉430071

出　　处：《重庆医学》2016年第3期383-386,共4页Chongqing medicine

基　　金：国家自然科学基金资助项目(30873044;81272372);教育部留学回国人员科研启动基金资助项目(教外司留[2011]1139号)

摘　　要：目的评价PTEN蛋白表达与乳腺癌患者临床病理学特征的关联性。方法通过PubMed、Embase、Cochrane Library、中国知网（CNKI）及万方数据库检索所有已发表的关于乳腺癌患者组织中PTEN蛋白表达与临床病理学参数的相关性研究。应用RevMan 5.2软件进行分析,计算表达比值比（OR）和95%可信区间（CI）,并对研究文献进行异质性检验和偏倚评估。结果共28篇研究文献（3 172例患者）纳入Meta分析。PTEN在乳腺癌组织中的表达与患者的雌激素受体（OR=3.16,95%CI：2.01~4.97,P〈0.01）、孕激素受体（OR=2.27,95%CI：1.70~3.04,P〈0.01）、淋巴转移（OR=0.36,95%CI：0.27~0.49,P〈0.01）、临床分期（OR=2.59,95%CI：2.04~3.30,P〈0.01）和组织学分级（OR=2.19,95%CI：1.74~2.75,P〈0.01）均有显著相关性。结论 PTEN异常表达可能在乳腺癌的发生、进展、浸润及预后中起重要作用,是乳腺癌早期诊断和内分泌治疗中较有价值的分子标志物。Objective To evaluate the association between the expression of PTEN protein and the clinicopathological char- acteristics of breast cancer patients. Methods All eligible studies regarding the association of PTEN protein expression with clini- copathological features in patients with breast cancer were retrieved from PubMed, Embase,Cochrane Library,CNKI and Wanfang databases. Odds ratio（OR） with corresponding 95 % confidence interval（95% CI） form eligible studies were pooled. Heterogeneity and publication bias were also evaluated. All analyses were operated using RevMan 5.2 software. Results A total of 28 articles con- taining 3 172 patients were ultimately included for this Meta-analysis. Our findings revealed that the expression level of PTEN was significantly correlated with estrogen receptor status （OR = 3.16,95 %CI ： 2.01 - 4.97, P 〈 0. 01 ）, progesterone receptor status （OR=2.27,95%CI：1.70-3.04,P〈0. 01）,lymph node metastasis（OR=0. 36,95%CI ：0. 27-0.49,P〈0. 01）,clinical stage （OR=2.59,95%CI：2.04-3.30,P〈0.01） and histological grade（OR=2.19,95%CI： 1.74-2.75,P〈0.01）. Conclusion Aber- rant PTEN expression might have strong impacts on carcinogenesis, tumor progression, invasion and prognosis, which makes it a potential biomarker for early cancer screening and endocrine therapy in breast cancer.

关 键 词：乳腺肿瘤 肿瘤抑制蛋白质类 PTEN 雌激素受体 临床病理学特征 META分析 

分 类 号：R737.9[医药卫生—肿瘤]