FISH检测t（11；14）对于七例不典型套细胞淋巴瘤的诊断意义  

Clinical significance of detecting t （11 ; 14 ） by fluorescence in situ hybridization for the diagnosis of 7 patients with atypical mantle cell lymphoma

作　　者：朱剑锋[1] 吴正东[1] 范磊[2] 徐卫[2] 李建勇[2] 

机构地区：[1]南通大学附属泰州市人民医院血液科,江苏省泰州市225300 [2]南京医科大学第一附属医院、江苏省人民医院血液科,210029

出　　处：《中华医学遗传学杂志》2016年第1期13-16,共4页Chinese Journal of Medical Genetics

摘　　要：目的探讨7例不典型套细胞淋巴瘤（mantlecelllymphoma，MCL）的临床特点与诊断。方法对7例因免疫表型积分为4分而误诊为慢性淋巴细胞白血病（chroniclymphocyticleukemia，CLL）的MCL患者的临床特点和诊断进行回顾。结果7例患者中浅表淋巴结肿大但难以触及者6例。所有患者均因广泛浸润骨髓被分为Ⅳ期，CLL免疫表型积分为4分，间期荧光原位杂交检测t（11；14）均为阳性。结论部分MCI。患者临床表现与CLL相似，间期荧光原位杂交检查将有助于其诊断。Objective To study the clinical features and diagnosis of 7 patients with atypical mantle cell lymphoma （MCL） . Methods The 7 MCL patients were misdiagnosed as chronic lymphocytic leukemia （CLL） due to a score of 4 for their immunophenotypes. The clinical features and diagnosis of such patients were retrospectively analyzed. Results Six patients had superficial lymphadeneetasis but their lymph nodes could not be palpated. All 7 patients were as stage IV considering bone marrow infiltration. Scores of immunophenotype of CLL were 4, and interphase fluorescence in situ hybridization （FISH） for t（11;14） were positive in all patients. Conclusion Some MCL patients have clinicai features similar to CLL. Interphase FISH can play an important role in the diagnosis of MCL.

关 键 词：套细胞淋巴瘤 不典型 t(11 14)易位 荧光原位杂交 

分 类 号：R733.1[医药卫生—肿瘤]