CETP基因1405V、D442G多态性与长沙汉族人脑出血及血脂水平的相关性  

Association of CETP gene I405V/D442G polymorphisms with cerebral hemorrhage and serum lipid profile in ethnic Han population from Changsha

作　　者：徐晓玉[1] 郑孝瑜 揭福平 曾艺 张乐[1] 

机构地区：[1]中南大学湘雅医院神经内科,长沙410008 [2]湘雅二医院老年病科

出　　处：《中华医学遗传学杂志》2016年第1期91-96,共6页Chinese Journal of Medical Genetics

基　　金：国家自然科学基金（30600199）;湖南省自然科学基金（13JJ3013）;国家教育部留学回国人员科研启动基金[（2013）1972];湖南省科技厅支撑计划项目（2013SK3009,2014FJ3138）;湖南省发改委科技基本建设项目（[2013]1199）

摘　　要：目的研究胆固醇酯转运蛋白（cholesterylestertransferprotein，CETP）基因1405V、D442G多态性与长沙汉族人群脑出血及血脂水平的相关性。方法选取170例脑出血患者及种族、年龄、性别匹配的191名健康对照组人群作为研究对象，采用聚合酶链反应一限制性片段长度多态性方法测定研究对象CETP基因1405V、D442G多态性，氧化酶法测定血脂，应用SPSSl6．0软件完成统计分析，比较两组之间两种基因多态性的分布情况及不同基因携带者的血脂水平。结果CETP基因1405V、D442G不同基因型及等位基因在脑出血组与对照组之间的分布差异均无统计学意义（P〉0．05））；CETP基因1405V多态性与脑出血患者或对照组人群血脂水平均无显著相关性（P〉0．05）；在脑出血患者中，CETP基因D442G多态性DG基因型携带者的总胆固醇及低密度脂蛋白胆固醇水平均显著高于DD基因型携带者（P〈0．05）。结论CETP基因1405V多态性可能与长沙汉族人群脑出血无关；CETP基因D442G多态性可能与长沙汉族脑出血患者血脂水平有关。Objective To assess the association between I405V and D442G polymorphisms of the CETP gene with cerebral hemorrhage （CH） and a related lipid profile among ethnic Han Chinese from Changsha. Methods A case-control study was carried out, which enrolled 170 cerebral hemorrhage patients and 191 ethnicity-, age- and sex-matched health controls. Polymerase chain reaction-restricted fragments length polymorphism （PCR-RFLP） was used to determine the polymorphis~＇ns. Lipid profile was determined by means of oxidase method. Statistic analyses were performed with SPSS 16.0. Results No significant difference was found in the CETP gene I405V and D442G genotypes and allelie distribution between the CH patients and controls （P^0.05）. There was no associatiorr between CETP gene I405V polymorphism and lipid profile in both groups （P〉0.05）. CH patients with DG genotype of the D442G polymorphism had higher TC and low density lipoprotein-cholesterol （LDL-C） levels than those with a DD genotype （P〈 0.05）. Conclusion CETP gene I405V polymorphism may not be associated with CH among ethnic Han Chinese from Changsha, while the D442G polymorphism of the CETP gene may be associated with TC and LDL levels in the same population.

关 键 词：CETP基因 基因多态性 血脂水平 脑出血 

分 类 号：R743.34[医药卫生—神经病学与精神病学]