从精准医学看结直肠癌诊断与治疗的未来  

Future diagnosis and treatment of colorectai cancer from the view of precision medicine

作　　者：姚宏伟[1] 舒畅[2] 胡松年[2] 刘荫华[3] 

机构地区：[1]北京大学第三医院普通外科,100191 [2]中国科学院北京基因组研究所 [3]北京大学第一医院普通外科,100034

出　　处：《中华胃肠外科杂志》2016年第1期7-12,共6页Chinese Journal of Gastrointestinal Surgery

摘　　要：我国的结直肠癌已经进入高发期。2015年是“精准医学”计划的启动之年。结直肠癌的“精准医学”就是在癌症基因组测序和信息分析基础上，解析结直肠癌发生、发展、侵袭、转移和复发的机制，有针对性地实施个体化治疗。由全球多个国家的专家组建的结直肠癌分型团队．整合以往以基因检测为基础的结直肠癌亚型分类系统．参考基因突变、拷贝数、甲基化、microRNA和蛋白质组学信息。建立了4个各具特征的共识分子亚型（CMSs）。其清晰的生物判读性，成为目前最有力的结直肠癌分类系统，并有望为建立临床精准治疗体系提供参考依据。China has entered a period of high incidence of eolorectal cancer. The year of 2015 is the start of precision medicine. Coloreetal cancer ＂precision medicine＂ is based on the analysis of the cancer genome sequencing and information analysis, interprets the mechanism of the occurrence, development, invasion, metastasis and recurrence of colorectal cancer, and helps to implement targeted individual treatment. The experts of the world＇s Coloreetal Cancer Subtyping Consortium, integrated the past genetic testing based on the classification of colorectal cancer subtypes, refered to the indices of gene mutation, copy number, methylation, microRNA and proteomics, and coalesce the types of colorectal cancer into four consensus molecular subtypes （CMSs） with distinguishing features. CMSs may be the most powerful classification system of colorectal cancer because of its clear biological interpretation, and is expected to provide a reference basis for the establishment of clinical precision treatment system.

关 键 词：结直肠肿瘤 精准医学 基因组 癌症 

分 类 号：R735.34[医药卫生—肿瘤]