胃肠间质瘤诊断与治疗的新挑战——从循证医学到精准医学的思考与实践  

New challenges in the diagnosis and treatment of gastrointestinal stromal tumor： thinking and practice from evidence-based medicine to precision medicine

作　　者：曹晖[1] 汪明[1] 

机构地区：[1]上海交通大学医学院附属仁济医院胃肠外科,200127

出　　处：《中华胃肠外科杂志》2016年第1期17-21,共5页Chinese Journal of Gastrointestinal Surgery

基　　金：国家自然科学基金（81272743）;上海市科学技术委员会基金（13411950902）

摘　　要：随着近年来的肿瘤分子诊断的发展及靶向药物的推广应用．癌症治疗已经逐步进入了精准医学新时代。胃肠间质瘤（gastrointestinal stromal tumor，GIST）的诊断和治疗充分体现了精准医学的理念．但是目前在GIST临床诊治的诸多方面（如基因突变与预后的相关性、野生型GIST的治疗策略以及耐药现象的应对等）还有不少亟待解决的难题需要探索。With the development of tumor molecular diagnosis and the administration of targeted drugs, cancer treatment has gradually entered a new era of precision medicine. The diagnosis and treatment of gastrointestinal stromal tumor （GIST） is a full embodiment of the concept of precision medicine, but there are still many problems needed to be solved in the clinical diagnosis and treatment of GIST （such as the correlation between the gene mutation and prognosis, the treatment strategy of wild type GIST and the drug resistance phenomenon）.

关 键 词：胃肠间质瘤 精准医学 诊断 治疗 

分 类 号：R735[医药卫生—肿瘤]