赖氨酰氧化酶家族影响脉络膜新生血管生成的机制  

Effects and mechanism of lysyl oxidase family in choroidal neovascularization

作　　者：徐文芹[1] 王雨生[1] 

机构地区：[1]第四军医大学西京医院眼科、全军眼科研究所,陕西省西安市710032

出　　处：《眼科新进展》2016年第1期81-83,共3页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号:81271014、81470655、81570856)

摘　　要：脉络膜新生血管(choroidal neovascularization,CNV)是多种眼底疾病共同的临床表现和病理改变,抗血管内皮生长因子药物是近年治疗CNV的有效手段之一,但依然存在耐药性和停药复发等问题。近年的研究发现,赖氨酰氧化酶家族在CNV的发生发展中具有一定的作用,有望成为CNV治疗的新方向。本文将阐述赖氨酰氧化酶家族在CNV生成中的作用机制。Choroidal neovascularization（CNV） is the common clinical manifestations and pathological changes in a variety of retinal diseases.In recent years,anti-vascular endothelial growth factor drugs are considered to be effective means in treating CNV,but there remain resistant and withdrawal relapse and other issues.Recent studies have found that lysyl oxidase family has a certain role in the development of CNV,and is expected to become the new strategy in the treatment of it.This article reviews the mechanism of lysyl oxidase family in CNV.

关 键 词：赖氨酰氧化酶 脉络膜新生血管 细胞外基质 新生血管 骨髓来源细胞 

分 类 号：R774.5[医药卫生—眼科]