三通输液连接器在卯巢癌腹腔积液患者腹腔热灌注中的应用  

Application of triple exits linker for temperature regulation of ovarian cancer patients with ascites during hyperthermic peritoneal perfusion

作　　者：王宝娜[1] 任宏涛[1] 焦菊凤 沈亚宁[1] 

机构地区：[1]西安交通大学第二附属医院肿瘤科,陕西西安710004

出　　处：《肿瘤》2016年第1期90-95,共6页Tumor

摘　　要：目的：探讨三通输液连接器在卵巢癌腹腔积液患者应用HGGZ-102型体腔热灌注机行腹腔热灌注过程中对温度调控的作用。方法：以2013年4月-2014年9月收治的未使用三通输液连接器的HGGZ-102型体腔热灌注机进行腹腔热灌注治疗的39例卵巢癌腹腔积液患者作为对照组：2014年10月-2015年5月收治的使用三通输液连接器的HGGZ-102型体腔热灌注机行腹腔热灌注治疗的45例卵巢癌腹腔积液患者作为研究组,2组患者均采用TP方案（紫杉醇联合顺铂）进行化疗（紫杉醇静脉滴注d 1,顺铂腹腔热灌注d 1和d 8）,每3周重复1次共进行6个周期的治疗。比较热灌注时2组灌注药物进入腹腔和抽出腹腔时的温度及疗效。结果：研究组患者3个循环药物进入腹腔的温度阈值均精准控制在43.5~44.5℃,抽出腹腔时的最高温度均接近或达到目标温度阈39.5~40.5℃;研究组患者腹腔积液治疗有效率为71.1%,对照组为46.2%,2组间比较差异有统计学意义（P〈0.05）;2组患者不良反应的发生率,则差异无统计学意义（P〉0.05）。结论：使用三通输液连接器进行卵巢癌腹腔积液患者的腹腔热灌注治疗,可以达到精准控温,提高热灌注化疗药物疗效及安全性的作用。Objective： To investigate the efficacy of triple exits linker for temperature regulation of ovarian cancer patients with ascites in hyperthermic intraperitoneal perfusion using HGGZ-102 type body cavity heat perfusion machine. Methods： From April 2013 to September 2014, 39 ovarian cancer patients with ascites did not use triple exits linker （as the control group）. From October 2014 to May 2015, 45 ovarian cancer patients with ascites used triple exits linker during hyperthermic intraperitoneal perfusion （as the study group）. The patients in two groups were treated with TP regimen （paclitaxel on d 1, and hyperthermic peritoneal perfusion with cisplatin on d 1 and d 8; repeated every 3 weeks with a total of six cycles）. The temperature of the drugs inflowing into abdominal cavity and outflowin9 from abdominal cavity in two groups was examined. Results： In the study group, the threshold temperatures of the drugs inflowing into abdominal cavity for three cycles were precisely controlled at 43.5-44.5 ~C, and the maximal temperature when drugs outflowing from abdominal cavity reached target temperature （39.5-40.5 ~C）. The effective rates of ascite subsided were 71.1% and 46.2% in the study group and the control group, respectively. There was significant difference between the two groups （P 〈 0.05）. The incidence rate of adverse reaction between the two groups had no statistically significant difference （P 〉 0.05）. Conclusion： Application of triple exits linker for temperature regulation of ovarian cancer patients with ascites in hyperthermic intraperitoneal perfusion can control the temperature accurately and improve the therapeutic effect.

关 键 词：卵巢肿瘤 腹腔积液 抗肿瘤联合化疗方案 腹腔灌洗 

分 类 号：R737.31[医药卫生—肿瘤]