瘢痕疙瘩药物治疗研究进展  

Recent Development in Drug Treatment of Keloid

作　　者：李周娜[1] 朱莲花[1] 方宇辉[1] 金哲虎[1] 

机构地区：[1]延边大学附属医院皮肤科,吉林延吉133000

出　　处：《中国皮肤性病学杂志》2016年第2期196-199,共4页The Chinese Journal of Dermatovenereology

基　　金：国家自然科学基金项目(81060233);吉林省教育厅"十二五"科学技术研究项目[吉教科合字(2012)第2号];吉林省卫生厅项目(2011Z085);吉林省卫生厅项目(2014Z094);吉林省产业技术研究与开发项目(2013C034);延边大学科研项目[延大科合字(2012)第55号]

摘　　要：瘢痕疙瘩具有持续增生力,其实质是纤维组织肿瘤,不仅影响皮肤外观且其不断增生引发皮肤破溃、炎症反应,且影响身心健康。目前针对瘢痕疙瘩的治疗主要为手术、药物、激光等治疗方法,但手术后复发却严重影响治疗效果,因此药物综合治疗现在成为目前治疗热点。药物治疗一般用于小面积增生性瘢痕,目前治疗瘢痕疙瘩的药物很多,主要包括三类:第一类是细胞外基质靶向药物,第二类是细胞靶向药物,第三类是生化微环境靶向药物。本文就三种瘢痕疙瘩药物治疗的发展现状及最新药物的研究进展做一综述。The essence of keloid was continuous proliferation of fibrous tissue, which not only affects the appearance of the skin, but also causes skin ulceration, inflammatory reaction, and affects the physical and mental health. Currently keloid treatment is mainly surgery, medicine and laser treatment, but postoperative recurrence has seriously affected the therapeutic effect, so medication now become the main treatment. Medication is generally used in a small area of hypertrophic keloid. The main medicine includes three classes of drugs. The first is target to the extracellular matrix. The second kind is target to cells. The third is to biochemical microenvironment. In this paper, the development status of three kinds of drugs for the treatment of keloid and the research progress of the latest drugs are reviewed.

关 键 词：瘢痕疙瘩 药物治疗 研究进展 

分 类 号：R739.5[医药卫生—肿瘤]