戊己胃漂浮缓释片对无水乙醇型胃溃疡家兔的作用机理研究  

Study on the Action Mechanism of Wuji Gastric Floating Sustained-Release Tablets on Gastric Ulcers Induced by Anhydrous Ethanol in Rabbits

作　　者：陈中芬[1] 刘文[1] 吴增光[1] 张建峰[1] 王钰乐 杨道斌[1] 

机构地区：[1]贵阳中医学院,贵州贵阳550002

出　　处：《贵阳中医学院学报》2016年第1期16-20,共5页Journal of Guiyang University of Chinese Medicine

基　　金：国家自然科学基金资助项目;项目编号:No.81460609

摘　　要：目的:观察戊己胃漂浮缓释片对无水乙醇致家兔胃黏膜损伤的病理改变,探讨其可能的作用机制。方法:将家兔随机分为空白组、模型组、戊己胃漂浮缓释片低剂量组、戊己胃漂浮缓释片高剂量组、戊己丸组、西咪替丁组,每组各6只。连续给药12d,采用无水乙醇法致家兔胃黏膜损伤为模型,测定溃疡指数及病理损伤程度,并用ELISA法测定血清中NO、SOD、MDA及胃组织中PGE2的含量。结果:与模型组相比,各给药组均能显著降低无水乙醇型胃溃疡家兔的溃疡指数,升高家兔血清NO、SOD及胃组织PGE2的含量,降低血清MDA的含量,差异有统计学意义(P<0.05)。结论:戊己胃漂浮缓释片对无水乙醇法致家兔胃粘膜损伤有保护作用,其作用机制可能与调节NO、SOD、PGE2、MDA等的表达有关。Objective ：To explore the possible mechanism of Wuji gastric floating sustained-release tablets, and to observe the pathological changes of gastric mucosal injury induced by anhydrous ethanol in rabbits. Methods：The rabbits were randomly divided into a normal group and a model group： Wuji gastric floating sustained-release tablets low-dose group, wuji floating sustained high-dose group, and wuji pill group and cimetidine group. After 12 days of treatment, ethanol-induced gastric mucosal injury in rabbits as a model, the ulcer index and degree of pathological injury were measured, meanwhile, the contents of NO, SOD, MDA in serum and PGE2 in gastric tissue were measured with ELISA. Results：Compared with the model group, the ulcer index of each treated group were significantly lower than that of the model group, elevated the contents of NO,SOD in serum and PGE2 in gastric tissue, reduced the contents of MDA in serum. The difference was statistically significant（ P 〈 0. 05 ）. Conclusion： Wuji gastric floating sustained-release tablets showed obvious protective effect on gastric mucosa injury, and its mechanism may be related to the expression of regulating NO, SOD, PGE2, MDA, etc.

关 键 词：无水乙醇型胃溃疡 戊己胃漂浮缓释片 NO SOD MDA PGE2 

分 类 号：R446.1[医药卫生—诊断学]