首发未服药重性抑郁症患者静息态脑镜像同伦功能连接的差异  

Interhemispheric resting-state functional connectivity difference in first-episode medication-naive major depressive disorder patients

作　　者：刘艳丽[1] 魏新华[1] 王海林[1] 吴可通 胡键浠 徐向东[1] 

机构地区：[1]广州医科大学附属广州市第一人民医院放射科,广东广州510180 [2]中山大学附属第六医院放射科,广东广州510065 [3]广州医科大学附属广州市第一人民医院神经内科,广东广州510180

出　　处：《中国医学影像技术》2016年第2期191-194,共4页Chinese Journal of Medical Imaging Technology

基　　金：广州市科技计划项目(2014J4100071);广东省科技计划项目(2013B021800063)

摘　　要：目的探讨首发未服药重性抑郁症(MDD)患者大脑镜像脑区的功能连接的差异性。方法对27例临床诊断为MDD且为首发未用药的患者(MDD组)和21名健康志愿者(对照组)行常规MRI及静息态功能成像(rs-fMRI),对rsfMRI数据采用镜像同伦连接(VMHC)分析方法,并对两组被试差异脑区的VMHC值与汉密尔顿抑郁量表(HAMD)评分进行相关分析。结果与对照组比较,MDD组患者的双侧额上回、后扣带回、舌回的VMHC值增加,上述差异脑区VMHC值与HAMD评分无显著相关性。结论首发未服药MDD患者静息状态下多个大脑半球镜像脑区之间功能连接增加,可能为理解MDD的病理生理机制提供一个新的视角。Objective To explore the functional connectivity difference of the brain-mirrored regions in first-episode medication-naive major depressive disorder （MDD） patients. Methods Twenty-seven patients with first-episode medication-naive MDD （MDD group） and 21 healthy controls （control group） underwent MRI and rest-state functional magnetie reso- nance imaging （rs-fMRI）. The data of rs-fMRI were analyzed using Voxel-mirrored homotopic connectivity （VMHC）, and the correlation between VMHC values and the Hamilton depression scale （HAMD） scores in MDD subjects was investigated. Results Compared with control group, VMHCs of the bilateral superior frontal gyrus, posterior cingulates and lingual gyrus increased in MDD group. No significant correlation between the VMHC values and the HAMD scores was found. Conclusion Increased interhemispheric functional connectivity in many brain area may provide a new perspective in understanding the physiopathologic mechanism of MDD.

关 键 词：抑郁症 磁共振成像 镜像同伦连接 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]