首发精神分裂症幻听患者的全脑白质变化研究  

A study of whole brain white matter changes in patients with first-episode schizophrenia hallucinations

作　　者：李陈[1] 席一斌[1] 陈纲[1] 田萍[1] 崔龙彪[1] 刘康[1] 吴雨静[1] 印弘[1] 

机构地区：[1]第四军医大学西京医院放射科,陕西西安710032

出　　处：《实用放射学杂志》2016年第1期1-4,共4页Journal of Practical Radiology

基　　金：国家重点基础研究发展计划项目（2011CB707805）.

摘　　要：目的 探讨首发精神分裂症（SCH）幻听患者的全脑白质微细结构的改变。方法 分别对25例首发SCH幻听患者和25例正常对照者行扩散张量成像（DTI）扫描，采用基于纤维束示踪的空间统计分析（TBSS）方法分析2组全脑各向异性（FA）图，使用非参数的随机排列检验（random permutation test）对2组全脑DTI的FA值进行统计分析比较，得出有差异的脑区。结果 与正常组相比，首发SCH幻听组左侧额眶回与顶下小叶的白质FA值明显降低，差异具有统计学意义（P〈0.05）。结论 TBSS方法能较全面、准确地分析首发SCH幻听患者早期脑白质细微结构的改变。Objective To study whole brain white matter changes in first-episode schizophrenia patients with auditory hallucination. Methods DTI changes of 25 first-episode schizophrenia patients with auditory hallucination and 25 cases of normal control were analyzed respectively. Whole brain FA （ fractional anisotropy） figure was analyzed by spatial statistical analysis which based on TBSS （ tract-based spatial statistics） methods on both groups. DTI, FA values on two groups were analyzed by using random permutation test （RPT） in order to get the cerebral-regions differences. Results Compared with normal control group, FA values of the left orbit frontal cortex and inferior parietal lobule in the first-episode schizophrenic with auditory hallucination group were decreased signifi cantly （P〈0.05）. Conclusion TBSS method can be more comprehensive and accurate analysis of early cerebral white matter changes for first-episode schizophrenia patients with auditory hallucination.

关 键 词：首发 精神分裂症 幻听 扩散张量成像 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]