贲门癌人表皮生皮生长因子受体-2的表达及其临床病理意义  

Expressions of Cerb B-2 in Gastric Cardia Cancer in High Incidence Area and Its Clinicopathological Significance

作　　者：刘淑慧[1] 洪良利[2] 黄杰雄[2] 周宋霞 陈广灿[2] 

机构地区：[1]汕头大学医学院病理教研室,广东汕头515041 [2]汕头大学医学院第一附属医院,广东汕头515041

出　　处：《现代医院》2016年第1期14-16,共3页Modern Hospitals

基　　金：广东省自然科学基金(编号:2014A030310139)

摘　　要：目的探讨贲门癌中人表皮生长因子受体-2（CerbB-2）的表达及其与贲门癌临床病理特征的关系。方法随机选取2007年9月～2014年10月外科手术治疗的贲门癌病例114例，应用免疫组化（EnVision二步法）检测手术切取的肿瘤组织CerbB-2的表达，并分析其与，临床病理参数的相关性。利用Youdenindex法绘制患者的年龄和肿瘤最长径ROC曲线。结果CerhB-2在贲门癌中的阳性表达率为59．65％（68／114）。利用ROC曲线确定年龄和最长径的切点值分别为60岁和5cm。结果显示CerbB-2的阳性表达与瘤体的最长径相关（P=0．014），而与其它临床病理特征无关（P〉0．05）。结论CerhB-2在贲门癌中高表达，可能促进贲门癌的生长，对评估肿瘤的生物学行为有一定的指导意义。Objective To study the relationship between the expressions of CerbB -2 and clinicopathological features of gastric cardia cancer. Methods 114 patients with gastric cardia cancer from September 2007 to October 2014 undergoing surgical procedures were randomly selected. Expressions of CerhB -2 in tumor tissues obtained intraoperatively were detected by immunohistochemistry technique （EnVision method）. The correlation between the expressions and clinicopathologic parameters was analyzed. A receiver operating characteristic （ROC） curve of age and maximum tumor diameter was generated by Youden index method. Results The positive expression rate of CerbB - 2 in gastric eardia cancer was 59.65% （68/114）. The age and maximum tumor diameter cutoff on the ROC curve were 60 and 5cm, respectively. The results indicated that the positive expression of CerbB - 2 was associated with maximum tumor diameter（ P = 0. 014 ）, but not with other clinicopathological features （ P 〉 0. 05 ）. Conclusion High expression of CerbB - 2 in gastric cardia cancer may accelerate the growth of gastric cardia cancer, which is significant for the assessment of biologic behavior of gastric cardia cancer.

关 键 词：人表皮生长因子受体-2 贲门癌 临床病理特征 

分 类 号：R730.23[医药卫生—肿瘤] R735.2[医药卫生—临床医学]