犬瘟热病毒H基因变异及其细胞受体研究进展  

Progress on Canine Distemper Virus H Gene Mutation and Its Cell Receptor

作　　者：曾杨茹 王娅[1] 郗立新 文彩芳[1,2] 赵姗[1,2] 杨锐[1,2] 任露[1,2] 颜其贵[1,2] 

机构地区：[1]四川农业大学动物医学院,四川成都311130 [2]四川农业大学动物疫病与人类健康四川省重点实验室,四川成都311130

出　　处：《动物医学进展》2016年第2期70-74,共5页Progress In Veterinary Medicine

基　　金：国家科技支撑计划课题(2012BAC01B06);973计划前期研究专项(2012CB722207);减毒沙门氏菌递呈的大熊猫源轮状病毒VP4/VP7双基因疫苗的构建与免疫诱导规律研究(CPF研2012-12);大熊猫轮状病毒荧光定量PCR检测方法的建立与应用(CPF研2012-09)

摘　　要：犬瘟热(CD)是由犬瘟热病毒(CDV)引起的一种急性、高度接触性传染病。通过对CDV血凝蛋白(H)基因序列分析证实,野生动物暴发CDV野毒株感染与CDV H蛋白变异有极大关系。H蛋白主要影响CDV的抗原性、宿主范围和组织嗜性,其高变异率使CDV种间传播现象加剧,并扩大CDV宿主范围至灵长类猕猴。目前已发现2种CDV的细胞受体,即信号淋巴细胞激活因子(SLAM)和黏连蛋白4(PVRL-4/nectin-4),PVRL-4是2011年新发现的上皮细胞受体。SLAM和PVRL-4受体在哺乳动物体内的广泛存在为解释CDV对多种肉食动物具有易感性这一现象提供理论基础。论文对CDV H蛋白功能和其高变异率进行了概述,并结合H蛋白变异和其2个受体在CDV感染中的作用,以及对CDV宿主范围扩大现象进行阐述。Canine distemper （CD） caused by canine distemper virus（CDV） is an acute and highly contagious disease. According to the sequence and phylogenetic analysis of CDV H gene, the outbreak in wildlife might be associated with H protein amino acid exchange. The H protein mainly affects CDV antigenicity, the host range and tissue tropism, and results in an inter-species transmission and host range expansion to primates. Two kinds of CDV cell receptors have been found： Signaling lymphocytic activation molecule （SLAM） and nectin-4（PVRL-4/neetin-4） that was found to show as CDV receptor in 2011. The wide range of SLAM and PVRL-4 receptors in mammals is a theoretical basis for the interpretation of CDV suscepti- bility to a variety of carnivorous animals. In this paper, the function of H CDV protein and its high muta- tion rate were summarized, and the H protein variation and two receptor interactions with CDV were de- scribed.

关 键 词：犬瘟热病毒 H基因 变异 细胞受体 

分 类 号：S852.659.5[农业科学—基础兽医学]