细胞自噬作用在阿尔茨海默病治疗过程中的作用  

Role of cell autophagy in treatment of Alzheimer's disease

作　　者：朱朋胤 姜忠伟[2] 车皓月 潘勇华[1] 高申[1] 王忠壮[1] 傅芃[1] 

机构地区：[1]第二军医大学长海医院药学部,上海200433 [2]甘肃省军区门诊部,兰州730000 [3]第二军医大学药学院,上海200433

出　　处：《第二军医大学学报》2016年第1期77-82,共6页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金(81402819,81373327);上海市自然科学基金(13ZR1408500);总后勤部卫生部基金面上项目(14ZJ202-3)~~

摘　　要：阿尔茨海默病(Alzheimer’s disease,AD)是一种以进行性认知障碍和记忆力损害为主的脑部神经退行性疾病,其发病机制尚未明确,目前仍无有效的治疗方法。自噬在清除异常积聚的蛋白以及受损细胞器、维持细胞内稳态和细胞代谢中扮演重要角色。本文对细胞自噬作用在AD治疗过程中的作用进行了综述,以期为发现AD的新的治疗靶点提供参考。Objective Alzheimer＇ s disease （AD）is a brain neural degenerative disease characterized by progressive cognitive and memory impairment. The pathogenesis of Alzheimer＇ s disease remains unclear and there has been no effective treatment up to now. Autophagy plays an important role in clearing abnormally accumulated proteins and damaged organelles and in maintaining intracellular homeostasis and cell metabolism. This paper reviewed the role of autophagy in treatment of Alzheimer＇s disease, hoping to provide reference for discovering new treatment target for Alzheimer＇s disease.

关 键 词：阿尔茨海默病 自噬 淀粉样Β蛋白 

分 类 号：R749.16[医药卫生—神经病学与精神病学]