TGF-β_1/Smad通路对机械力诱导的胶原代谢调控的研究进展  

The Accommodative Function of TGF-β_1/ Smad Pathway on Collagen Metabolism Induced by Mechanical Force

作　　者：张琦钒 洪莉[1] 

机构地区：[1]武汉大学人民医院妇产科

出　　处：《医学综述》2016年第2期209-212,共4页Medical Recapitulate

基　　金：国家自然科学基金面上项目(81270684)

摘　　要：胶原是构成细胞外基质(ECM)的骨架。在正常生理状态下,其合成和降解处于动态平衡。胶原代谢失衡可引起一系列病理生理变化,导致疾病的发生,如血管重构、皮肤瘢痕增生等。女性盆底功能障碍性疾病患者盆底支持组织中存在着机械力诱导的胶原代谢异常转化生长因子(TGF)β_1/Smad信号转导通路是调控机体组织纤维化的最重要机制之一。目前关于女性盆底功能障碍性疾病与TGF-β_1/Smad通路之间关系的报道较少。该文就TGF-β_1/Smad信号转导通路对机械力诱导的ECM胶原代谢的影响及相关机制进行综述。Collagen is a skeleton of the extracellular matrix（ECM）. Under normal condition, the synthesis and degradation of collagen is in dynamic equilibrium. The imbalance of it can cause a series of patho-physiological changes and cause diseases such as vascular remodeling,hypertrophic scar and so on. Collagen metabolism abnormalities induced by mechanical force exists in female patients with pelvic floor dysfunction. Transforming growth factor（TGF） [3t/Smad signalling pathway is one of the most important pathways of regnlation on tissue fibrosis. At present, there are few articles about the relation of female pelvic floor dysfunction and TGF-β/Smad pathway. Here reviews the accommodative function and related mechanisms of TGF-β/Smad pathway on ECM collagen metabolism induced by mechanical force.

关 键 词：胶原代谢 纤维化 转化生长因子β1/Smad通路 机械力 氧化应激 

分 类 号：R363[医药卫生—病理学]