鹅掌柴叶挥发油的成分分析及抗炎镇痛活性  

Constituent analysis,analgesic and anti-inflammatory activities of leaves essential oil of Schefflera octophylla

作　　者：庞素秋[1,2] 金孝勤 孙爱静[1,2] 王国权[2] 许瑞安[2] 

机构地区：[1]解放军180医院药学科,福建泉州362000 [2]华侨大学生物医学学院与华侨大学分子药物研究院,福建泉州362021

出　　处：《药学实践杂志》2016年第1期56-58,78,共4页Journal of Pharmaceutical Practice

基　　金：福建省科技重点项目(2012Y0049)

摘　　要：目的 探讨鹅掌柴新鲜叶挥发油的化学成分及其抗炎镇痛作用。方法 采用水蒸气蒸馏法得到鹅掌柴叶挥发油（SOLEO）,用气相色谱-质谱联用技术（GC-MS）进行SOLEO成分的定性定量分析,并用醋酸扭体法、二甲苯致小鼠耳郭肿胀法两种模型评价SOLEO的抗炎镇痛活性。结果 GC-MS法测出SOLEO中55个组分,其中组分1~16共占84.28%,为SOLEO的主要成分。4-萜品醇、（-）-斯巴醇、氧化石竹烯、芳樟醇4种成分占总含量的51.86%。SOLEO可明显减少醋酸所致小鼠的扭体次数,可明显缓解二甲苯所致小鼠的耳郭肿胀程度,SOLEO经灌胃给药10g生药/（kg.d）剂量组的抑制率分别为52.5%和59.6%。结论 SOLEO为鹅掌柴抗炎镇痛药理作用的活性成分之一,为民间以鹅掌柴新鲜叶入药提供科学依据。Objective To investigate the constituents and analgesic and anti-inflammatory effects of leaves essential oil in Schefflera octophylla. Methods SOLEO was dilated by water vapor. The mouse acetic acid-induced twisting test and mouse auricle swelling test induced by xylene were employed to evaluate the anti- inflammation and analgesia effects of SOLEO. Results 55 constituents of SOLEO were identified by GC-MS. The major constituents, 4-terpenol, （-）-spthulenol, caryo phllene oxide and β-1inalool with total percent of 51.86 % were found. The twisting number and relieve swollen auricle of mice induced by xylene were significantly reduced by SOLEO. Conclusion SOLEO was the major active components of anti- inflam mation and analgesia.

关 键 词：鹅掌柴 挥发油 气相色谱-质谱联用技术 抗炎镇痛活性 

分 类 号：R285.5[医药卫生—中药学]