胡椒酸1.6-己二醇双酯的合成、结构表征和降血脂活性研究  

Synthesis,Characterization,and Anti-hyperlipidemic Activity of 1,6-Hexanediol Piperinicdiester

作　　者：宝贵荣[1,2] 孟和[2] 娜日苏[2] 昭日格图[2] 博.格日勒图[2] 

机构地区：[1]呼和浩特职业学院生物化学工程学院,呼和浩特010051 [2]内蒙古大学高分子化学及蒙药研究所,呼和浩特010021

出　　处：《内蒙古大学学报（自然科学版）》2016年第1期46-50,共5页Journal of Inner Mongolia University：Natural Science Edition

基　　金：国家自然科学资助项目(No.30160103);内蒙古自然科学基金(No.2014MS0216)

摘　　要：以蒙药药材荜茇为起始原料,经提取、分离、水解、酯化等过程,得到胡椒酸1,6-己二醇双酯,为一种新型的胡椒碱衍生物.通过红外光谱、碳氢核磁共振、紫外光谱和元素分析等分析手段,确证了该胡椒碱衍生物的化学结构,初步研究了其降血脂活性.结果表明胡椒酸1,6-己二醇双酯具有良好的降血脂和降血糖活性.A novel hexathyleneglacol piperinicdiester （HGPD） was synthesized successfully for the first time. The compound of HGPD was synthesized from Piperic acid and hexathyleneglacol. Pi peric acid was obtained by hydrolyzing piperine that was extracted from seeds of Piper longum L, which is a traditional Mongolian medicine. The structure of novel piperinicdiester was characterized by IR,13CNMR,1 HNMR and UV spectroscopies and elemental analysis. Anti-hyperlipidemic activi ty of HGPD was assayed by pharmacological tests and the results indicated that the HGPD had high anti-hyperlipidemic activity.

关 键 词：荜茇 胡椒酸 双酯 降血脂活性 

分 类 号：O62[理学—有机化学]