首发抑郁症患者静息态脑结构网络的变化及其意义  

Changes and significance of resting state brain structure network in patients with depression

作　　者：陈旭丹[1] 胡孝朋[2] 陶龙香 梁振[3] 余永强[1,2] 

机构地区：[1]安徽医科大学第四附属医院放射科,合肥230022 [2]安徽医科大学第一附属医院放射科,合肥230022 [3]安徽医科大学生物医学工程系,合肥230022

出　　处：《安徽医科大学学报》2016年第2期222-226,共5页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金项目(编号:31400943)

摘　　要：目的探讨抑郁症患者两大脑半球脑结构网络与正常对照者间的差异。方法选取33例首发抑郁症患者及25例性别、年龄及受教育年限相匹配的正常对照者进行功能磁共振扫描,分析两组受试者脑结构网络之间的差异以及这些脑区间距离与汉密尔顿评分(HAMD)之间的相关性。结果与对照组相比,抑郁症组右侧眶部额下回与后扣带回、右侧后扣带回与海马旁回、右侧梭状回与楔前叶的脑结构网络间距离显著增加(P<0.005),右侧海马旁回与苍白球的脑结构网络间距离明显缩短(P<0.005),相关分析结果提示这4对脑区间距离与HAMD评分两两相关。结论抑郁症患者多对脑区结构网络存在异常,在抑郁症的发病机制中发挥重要作用。Objective To explore the difference of interhemispheric brain structure between depression patients and healthy patients. Methods Thirty-three patients with first episode depression patients and twenty-five healthy person were selected as controls matched for age, gender and education. All subjects underwent fMRI scan. Analysis were conducted on two groups of subjects brain structure network and compared the differences between the two groups, and the linear relationship between the distance of these brain regions with HAMD scores. Results Compared with the control group, depression patients showed significantly increased distance in structure network of brain regions between right orbital frontal gyrus and posterior cingulate, right posterior cingulate and parahippocampal gyrus, right fusiform and precuneus （ P 〈 0. 005 ） , and significantly decreased in parahippocampal gyrus and globus pallidus（ P 〈 0. 005 ）. Correlation analysis showed that four pairs of brain interval distance were accociated with HAMD scores. Conclusion Depression patients show abnormality in structure network of brain regions, which plays an important role in the pathogenesis of depression.

关 键 词：抑郁症 弥散张量成像 脑结构网络 

分 类 号：R749.4[医药卫生—神经病学与精神病学]