无症状脑梗死认知障碍的相关危险因素分析  

Analysis of related risk factors for cognitive impairment in patients with silent cerebral infarction

作　　者：徐磊[1] 高春岭[1] 刘玉洁[1] 魏江山 谭华[1] 

机构地区：[1]泸州医学院附属医院神经内科,四川泸州646000

出　　处：《重庆医学》2016年第4期481-483,共3页Chongqing medicine

摘　　要：目的探讨无症状脑梗死（SCI）患者认知障碍的发生率及其相关危险因素。方法连续收集该院SCI患者98例,采用中文版蒙特利尔认知量表（MoCA）进行评分,将其分为认知障碍组及非认知障碍组,比较两组间相关因素的差异,将具有统计学意义的因素进入多因素分析,采用二分类非条件Logistic回归分析研究各因素对结果的影响。结果本组SCI患者认知障碍发生率为59.18%（58例）。认知障碍组中男性比例较高,受教育年限较低,具有较高的三酰甘油（TG）、尿酸（UA）及白细胞介素-6（IL-6）。多因素Logistic回归分析表明教育年限（OR：0.222,95%CI：0.076-0.647,P=0.006）,UA（OR：1.068,95%CI：1.013-1.126,P=0.015）,IL-6（OR：1.803,95%CI：1.103-2.945,P=0.019）与认知障碍相关。结论 SCI患者具有较高的认知障碍发生率,教育年限越低,UA及IL-6越高可能是SCI患者认知障碍的危险因素。Objective To investigate the incidence of cognitive impairment and its related risk factors in the patients with silence cerebral infarction（SCI）.Methods A total of 98 consecutive patients with SCI in our hospital were selected,evaluated by adopting the Chinese version of Montreal Cognitive Assessment（MoCA）and divided into the cognitive impairment group and the non-cognitive impairment group.The differences in the related factors were compared between the two groups,and the factors with statistical significance were performed the multi-factor analysis.The dichotomy nonconditional Logistic regression analysis was adopted to investigate the influence of the various factors on the results.Results The incidence rate of cognitive impairment in 98 cases was 59.18%（58cases）,in the cognitive impairment group,males had higher proportion,educated-years was lower,triglyceride（TG）,uric acid（UA）and interleukin-6（IL-6）level were higher.The multi-factor Logistic regression analysis showed that the educated-years（OR：0.222,95%CI：0.076-0.647,P=0.006）,UA（OR：1.068,95%CI：1.013-1.126,P=0.015）and IL-6（OR：1.803,95%CI：1.103-2.945,P=0.019）were associated with the cognitive impairment.Conclusion The patients with SCI have higher occurrence rate of cognitive impairment,the low educated-years and high UA and IL-6levels may be the risk factors of cognitive impairment.

关 键 词：无症状脑梗死 认知障碍 尿酸 白细胞介素6 

分 类 号：R743.3[医药卫生—神经病学与精神病学]