母孕产期环境因素与孤独症谱系障碍的关联研究  

Relationship between prenatal and pregnancy environmental factors and autism spectrum disorder

作　　者：郑冬梅[1] 吕莹[2,3] 孙彩虹[2] 王佳[2] 梁爽[2] 夏薇[2] 武丽杰[2] 

机构地区：[1]中国人民解放军总医院海南分院妇产科,海南三亚572001 [2]哈尔滨医科大学公共卫生学院儿少卫生与妇幼保健学教研室,黑龙江哈尔滨150081 [3]北京市房山区妇幼保健院儿童早期综合发展研究中心,北京102400

出　　处：《哈尔滨医科大学学报》2015年第6期524-527,共4页Journal of Harbin Medical University

基　　金：国家自然科学基金资助项目(81302443)

摘　　要：目的探讨母孕产期环境因素与孤独症谱系障碍(autism spectrum disorder,ASD)发病的关联。方法采用病例-对照研究的方法,利用临床资料调查表,对80例ASD儿童和80例正常对照组儿童母孕产期环境因素进行调查与分析。结果单因素统计分析结果显示,母孕产期的环境因素中,ASD组母亲有人工流产史、孕期作息不规律、上行感染、高血压、孕期有情绪问题、服用或注射过药物、孕期主动吸烟或被动吸烟、饮酒史、接触有毒有害物质所占的比例均较正常组高(P<0.05);Logistic回归分析结果显示,孕期服用或注射过药物、孕期主动或被动吸烟、孕期作息不规律与孤独症的发病存在关联性。结论加强孕产期的保健管理,做好优生优育宣传,避免孕产期高危因素发生,有利于预防ASD的发生。Objective To examine the associations between pregnancy envirbnmental factors and autism spectrum disorder （ASD）. Methods Eighty parents of autistic children and 80 age-gender matched normal children＇ parents were recruited to receive investigation by the pre- natal and pregnancy factors questionnaire. Results The univariate analysis results showed that pregnancy irregular rest, infection, hypertension, emotional problem, drug exposure, smoking and alcohol exposure, poison exposure were significantly higher in ASD group than those in normal group （P 〈 0.05 ） ; In the logistic regression model, drug exposure, smoking and preg- nancy irregular rest had associations with ASD. Conclusion It is important to strengthen ma- ternal health care management and eugenic and superior nurture in order to prevent the happening of ASD.

关 键 词：孕产期环境因素 孤独症谱系障碍 病例-对照研究 

分 类 号：R749.94[医药卫生—神经病学与精神病学]