卡马西平、托吡酯与丙戊酸钠治疗脑炎继发癫痫的临床疗效  

Clinical Efficacy of Carbamazepine,Topiramate and Sodium Valproate in the Treatment of Epilepsy Secondary to Encephalitis

作　　者：石福宏[1] 吕秋杰[1] 

机构地区：[1]河南省安阳市第三人民医院,河南安阳455000

出　　处：《中国医学创新》2015年第33期122-124,共3页Medical Innovation of China

摘　　要：目的:观察卡马西平、托吡酯与丙戊酸钠治疗脑炎继发癫痫的临床疗效,并分析其临床意义。方法:随机选取2008年1月1日-2015年1月1日本院的60例脑炎继发癫痫患者的临床资料并行回顾性分析,根据临床用药方式将其分为卡马西平组、托吡酯组和丙戊酸钠组,每组20例。卡马西平组给予卡马西平口服治疗,托吡酯组给予托吡酯口服治疗,丙戊酸钠组给予丙戊酸钠口服治疗,记录比较三组的治疗结果和不良反应发生情况。结果:托吡酯的有效率最高,卡马西平的有效率最低,丙戊酸钠组的有效率居中,但三组总有效率比较差异无统计学意义(P>0.05);卡马西平组的不良反应发生率最高,托吡酯的不良反应发生率最低,丙戊酸钠组的不良反应发生率居中,三组不良反应发生率比较差异有统计学意义(P<0.05)。结论:在脑炎继发癫痫的临床治疗中,卡马西平、托吡酯和丙戊酸钠治疗的疗效相近,托吡酯的安全性最高,卡马西平的不良反应更多,可考虑于临床中合理筛选使用。Objective：To observe and analyze the clinical curative effect of Carbamazepine,Topiramate and Sodium Valproate on the treatment of epilepsy secondary to encephalitis,and to analyze its clinical significance.Method：60 cases of epilepsy secondary to encephalitis patients in our hospital from January 2008 to January 2015 were randomly selected,their clinical data were analyzed retrospectively.All patients were divided into the Carbamazepine group,the Topiramate group and the Sodium Valproate group according to clinical medication,with each group 20 cases.The Carbamazepine group was given Carbamazepine oral treatment,the Topiramate group was given Topiramate oral treatment,the Sodium Valproate group was given Sodium Valproate oral treatment.The treatment effect and the situation of adverse reactions were recorded and compared among the three groups.Result：The Topiramate group had the highest efficiency,the Carbamazepine group ranked third and the Sodium Valproate group ranked second,the difference in efficiency among the three groups was not statistically significant（P〉0.05）.The incidence rate of adverse reactions in the Carbamazepine group was the highest,the incidence rate of adverse reactions in the Topiramate group was the lowest,the incidence rate of adverse reactions in the Sodium Valproate group ranked second.The difference in the incidence rate of adverse reactions among the three groups was statistically significant（P〈0.05）.Conclusion：Carbamazepine,Topiramate and Sodium Valproate have similar effect in the treatment of secondary epilepsy.Topiramate has the highest safety,Carbamazepine has more adverse reactions compared with other two medicines.The three drugs shall be reasonably selected to use in clinic.

关 键 词：卡马西平 托吡酯 丙戊酸钠 脑炎继发癫痫 临床疗效 

分 类 号：R742.9[医药卫生—神经病学与精神病学]