乙型肝炎病毒对非酒精性脂肪肝患者肝功能及血清中成纤维细胞生长因子21的影响  

Effect of HBV on Liver Function and Serum FGF21 of Patients with Non-alcoholic Fatty Liver Disease

作　　者：王玉泽[1] 张海丛[2] 张冬[3] 戴二黑[2] 杨莉[2] 

机构地区：[1]石家庄市第五医院药剂科,石家庄050021 [2]石家庄市第五医院检验科,石家庄050021 [3]河北中医学院中西医结合学院,石家庄050200

出　　处：《解放军医药杂志》2016年第1期62-65,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：河北省中医药管理局科学技术研究计划(2012166)

摘　　要：目的探讨乙型肝炎病毒(HBV)对非酒精性脂肪肝(NAFLD)患者肝功能、胰岛素敏感性及成纤维细胞生长因子21(FGF21)的影响。方法选择2013年1月—2014年12月收治的脂肪肝58例,其中NAFLD组29例,慢性乙型肝炎(CHB)合并NAFLD组29例,选择同期正常人29例为正常对照组。观察3组肝功能、血糖、胰岛素指数及血清中FGF21的表达水平。结果 NAFLD组及CHB合并NAFLD组丙氨酸转氨酶、天冬氨酸转氨酶和FGF21均高于对照组(P<0.05)。CHB合并NAFLD组和NAFLD组空腹胰岛素(FINS)高于正常对照组,胰岛素敏感指数(ISI)低于正常对照组,且CHB合并NAFLD组FINS高于NAFLD组,ISI低于NAFLD组(P<0.05)。结论 NAFLD患者感染HBV后,胰岛素敏感性降低,代谢紊乱加重,肝脏损伤进一步加剧。Objective To investigate the effect of hepatitis B virus （HBV） on liver function, insulin sensitivity and the serum fibroblast growth factor 21 （ FGF21 ） of patients with non-alcoholic fatty liver disease （NAFLD）. Methods A total of 58 patients with fatty liver during January 2013 and December 2014 were recruited in this study, which in- cluded 29 patients with NAFLD and 29 patients with chronic hepatitis B （CHB） combined with NAFLD. A total of healthy 29 controls at the same period were recruited as a control group. The levels of liver function, blood glucose, insulin index and serum FGF21 expression also in the three groups were observed. Results The levels of alanine aminotransferase （ALT）, aspartate aminotransferase （AST） and FGF21 in NAFLD and CHB combined with NAFLD groups were significantly higher than those in the control group （P 〈 0.05）. The levels of fasting serum insulin （FINS） were significantly higher, while the values of insulin sensitivity index （ISI） were significantly lower in NAFLD and CHB combined with NAFLD groups than those in the control group; in CHB combined with NAFLD group, the FINS level was significantly higher, while the ISI value was significantly lower than those in NAFLD group （ P 〈 0. 05 ）. Conclusion If NAFLD patients are infected with the hepatitis B virus, the insulin sensitivity of the patients will decrease with metabolic disorder and further aggravated liver damage.

关 键 词：脂肪肝 非酒精性 乙型肝炎病毒 成纤维细胞生长因子21 

分 类 号：R575[医药卫生—消化系统]