罗汉果甜苷对芒果苷抗炎的协同效应  

Anti-inflammatory Synergy Effect between Mangiferin and Mogroside

作　　者：黄云[1] 胡文姬[2] 李学坚[1] 邱宏聪 刘布鸣 黄艳 杜正彩[1] 

机构地区：[1]广西中医药大学科学实验中心,广西南宁530001 [2]武汉市中医医院,湖北武汉430014 [3]广西中药质量标准研究重点实验室,广西南宁530022

出　　处：《广西科学》2015年第6期616-619,共4页Guangxi Sciences

基　　金：广西中药质量标准研究重点实验室开放课题基金项目(GXGZZK201102);广西高校重点实验室基金项目(2014年)资助

摘　　要：【目的】研究罗汉果甜苷和芒果苷在抗炎作用上是否存在交互作用。【方法】基于二甲苯致小鼠耳廓肿胀模型与醋酸致小鼠腹腔毛细血管通透性亢进模型,分别用罗汉果甜苷、芒果苷以及芒果苷+罗汉果甜苷作用,并利用析因方差分析研究3种组分的抗炎效果。【结果】与空白对照组比较,芒果苷组对于两个炎症模型均有抗炎作用(P<0.05),罗汉果甜苷组对于两个炎症模型均无抗炎作用(P>0.05)。芒果苷+罗汉果甜苷组对于两个炎症模型的抗炎作用(P<0.01)均强于芒果苷组,且两者之间有交互作用(P<0.05)。【结论】芒果苷有抗炎作用,而罗汉果甜苷在此用药剂量下没有抗炎作用;芒果苷与罗汉果甜苷合用,在抗炎作用中有明显的协同效应,说明罗汉果甜苷能显著提高芒果苷的抗炎药效。【Objective】The interaction effects between mangiferin and mogroside were investigated to explore their anti-inflammatory synergy.【Methods】Both mouse models of ear edema induced by xylene and increasing permeability of celiac capillary induced by acetic acid were employed to study the anti-inflammatory effects by means of factorial analysis of variance.【Results】Compared with blank control,anti-inflammatory effects of mangiferin are found in both mouse inflammatory models(P <0.05),whereas no anti-inflammatory effect of mogroside is found in any mouse inflammatory model(P >0.05).The anti-inflammatory effect in the group of mangiferin and mogroside is stronger than that in the group of mangiferin(P <0.01),andalso mangiferin and mogroside have interaction effects on anti-inflammatory synergy(P <0.05).【Conclusion】In expectorant test,there exists interaction effect between mangiferin and mogroside,and mogroside can significantly improve anti-inflammatory effect of mangiferin.

关 键 词：芒果苷 罗汉果甜苷 抗炎 析因分析 

分 类 号：R285.5[医药卫生—中药学]