DNA甲基化在常见眼科疾病中的研究进展  

The research progress of DNA methylation in common ocular diseases

作　　者：杜钰[1] 竺向佳[1] 卢奕[1] 

机构地区：[1]复旦大学附属眼耳鼻喉科医院眼科,上海200031

出　　处：《中国眼耳鼻喉科杂志》2016年第1期60-64,共5页Chinese Journal of Ophthalmology and Otorhinolaryngology

摘　　要：表观遗传学是近年新兴起的有别于传统遗传学的一门学科。它通过DNA甲基化、组蛋白共价修饰、非编码RNA调控等方式改变基因表达或细胞表型,这一改变能够遗传给子代,但DNA序列并未发生变化。DNA甲基化作为一种表观遗传学的重要机制,已被证实在大量复杂生命现象,比如衰老、氧化应激中起到作用。以往DNA甲基化的研究主要着重于全身性疾病,而在眼科领域的应用才刚刚兴起。本文重点介绍DNA甲基化在眼科常见疾病中的研究进展。Epigenetics is an emerging discipline studying the heritable regulation of gene function and celluar phenotype by means of DNA methylation, histone modification and non-coding RNA without changing DNA sequence, which is different from the traditional genetics. Being one of the most important mechanisms in epigeneties, DNA methylation is involved in a large number of complex biological phenomena, such as aging, oxidative stress, etc. Previously, the study of DNA methylation were mostly focused on systemic diseases, while in ophthalmology it just started. This article is an review of the research progress of DNA methylation in common ocular diseases.

关 键 词：表观遗传学 DNA甲基化 眼科疾病 

分 类 号：R77[医药卫生—眼科]