贲门失弛缓症的病因及发病机制研究进展  

Recent progress in etiology and pathogenesis of achalasia

作　　者：黄秀强[1] 曲波[1] 李惠[1] 

机构地区：[1]哈尔滨医科大学附属第二医院消化内科,黑龙江哈尔滨150086

出　　处：《胃肠病学和肝病学杂志》2016年第1期97-100,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：贲门失弛缓症(achalasia,AC)是一种病因尚不明确的食管运动功能障碍性疾病,以食管下括约肌(lower esophageal sphincter,LES)松弛障碍、食管蠕动异常为主要特点。遗传因素、环境因素、病毒感染及自身免疫等可能共同作用使食管肌间神经丛损伤,从而导致AC的发生。本文就近年来AC的病因及发病机制的进展作一概述。Achalasia （AC） is an unclear esophageal motility disorder disease characterized by impaired relaxation of the lower esophageal sphincter （LES） , absent or decreased esophageal aperistalsis. AC is caused by loss of inhibitory ganglion in the myenteric plexus of the esophagus. Genetic factors, environmental factors, viral infection and autoimmu- nity result in degeneration of inhibitory nerves in the esophagus. In this review, we discussed the current evidence of the pathogenesis and etiology of AC.

关 键 词：贲门失弛缓症 食管下括约肌 食管肌间神经丛 发病机制 病因 

分 类 号：R571[医药卫生—消化系统]