乳腺实性乳头状癌临床病理分析  

Clinicopathological analysis of solid papillary carcinoma of breast

作　　者：刘媛媛[1] 张伟[1] 齐殿军[2] 杨恩东[1] 张学义[1] 

机构地区：[1]抚顺矿务局总医院(中国医科大学第七临床医院)病理科,辽宁抚顺113008 [2]中国医科大学附属第一医院全科医学科,辽宁沈阳110001

出　　处：《中国实验诊断学》2016年第1期60-63,共4页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨乳腺实性乳头状癌(Solid papillary carcinoma,SPC)临床病理特点、诊断及其鉴别诊断。方法对13例SPC病例进行组织形态学观察及免疫组化标记,总结其临床资料和组织病理特征,选用抗体包括Syn、CgA、CD56等。结果本组13例均为女性患者,发病平均年龄63.7岁,肿瘤直径0.5cm-3cm(平均1.5cm),镜下可见肿瘤细胞在导管内实性膨胀生长,形成假菊形团样结构,导管内可见肿瘤细胞Paget样扩散,细胞核轻至中度异型,核分裂象<5个/10HPF。免疫组化显示瘤细胞弥漫表达ER、PR、Syn等,Ki67平均阳性指数为9%。结论 SPC具有较独特的病理组织学改变和免疫表型,诊断依靠形态学特征,免疫组化标记有助于与普通型导管上皮增生、小叶瘤变及低级别导管原位癌等相鉴别。Objective The aim of the study is to explore the clinicopathological features, diagnosis and differential diagnosis of breast solid papillary carcinoma （SPC）. Methods Histopathological observation and immunohistochemical labeling were applied to 13 SPC cases. Clinical data and histopathological features were summarized by using the anti- bodiesof Syn,CgA,CD56 ,etc. Results Thirteen female patients were recruited in the study, and the average age of on- set was 63.7 years. The diameter of the tumors was 0.5-3 cm （average 1.5 cm）. The intraductal tumor cells grew in solid expansion style, forming false chrysanthemum-like structure. The tumor cells were diffusing in Paget like type in the duct,and the nuclei exhibited mild to moderate atypia, mitoses 〈5/10HPF. Immunohistochemical staining showed that the tumor cells diffusely expressed ER,PR,and Syn etc. , and average positive index for Ki67 was 9 %. The diag nosis relies on morphological features, and the immunohistochemical markers are helpful in the differential diagnosis of ductal epithelial hyperplasia, lobular neoplasia and low grade ductal carcinoma in situ.

关 键 词：乳腺 实性乳头状癌 神经内分泌 

分 类 号：R737.9[医药卫生—肿瘤]