共济失调毛细血管扩张征突变基因多态性(rs189307)与肺癌易感性关系的Meta分析  

Association between polymorphism of Ataxia-telangiectasia mutated(rs189307)and the susceptibility of lung cancer:a Meta-analysis

作　　者：杨希夷[1] 乔光磊[1] 颜宏利[2] 马俐君[1] 

机构地区：[1]上海交通大学医学院附属同仁医院肿瘤科,上海200336 [2]第二军医大学附属上海长海医院实验诊断学科,上海200433

出　　处：《中国实验诊断学》2016年第1期81-84,共4页Chinese Journal of Laboratory Diagnosis

基　　金：上海市长宁区科学技术委员会项目(编号:CNKW2014J02)

摘　　要：目的综合评价共济失调毛细血管扩张征突变(ataxia-telangiectasia mutated,ATM)基因多态性(rs189307)与肺癌易感性的关系。方法应用计算机检索PubMed、EMBase、Cochrane Library、万方、中国知网和维普等数据库,按照纳入和排除标准选择文献,评价文献质量并提取资料,采用Stata 12.0软件进行Meta分析,计算ATM rs189307与肺癌易感性关系的合并比值比(odds ratio,OR),并进行亚组分析、发表偏倚检验和敏感性分析。结果最终纳入5项病例对照研究,共包括3036例患者和3415例正常对照。Meta分析结果显示,ATM rs189307AA基因型显著增加了亚洲人群肺癌的发病风险(GG vs AA,OR=0.83,95%可信区间(confidence interval,CI)=0.72-0.96,P=0.011;GG+GA vs AA,OR=0.86,95%CI=0.76-0.97,P=0.017)。在吸烟状况的亚组分析中,ATM rs189307AA基因型显著增加了非吸烟人群肺癌的发病风险(GG vs AA,OR=0.69,95%CI=0.56-0.86,P=0.001;GG+GA vs AA,OR=0.68,95%CI=0.56-0.82,P=0.000)。结论 ATM rs189307AA基因型是亚洲人群肺癌易感性增加的危险因素,尤其是对于非吸烟人群。Objective To evaluate the correlation between polymorphism of Ataxia-telangiectasia mutated （ATM） （rs189307） and the susceptibility of lung cancer. Methods A computer-based online search was performed by using PubMed, EMBase, Cochrane Library, Wanfang database, China National Knowledge Infrastructure （CNKI） and VIP da- tabase. The studies were selected according to defined inclusion and exclusion criteria. Then the quality evaluation and data abstraction were conducted. The meta-analysis was performed by using STATA 12. 0 software. The odds ratio （OR） of the association between polymorphism of ATM （rs189307） and the susceptibility of lung cancer was calculat- ed. Then the subgroup analysis,publication bias test and sensitivity analysis were performed. Results A total of 5 case- control studies were eligible for this analysis,involving 3036 patients and 3415 healthy controls. Meta-analysis showed that ATM rs189307 AA could significantly increase the risk of lung cancer in Asian （GG vs AA,OR=0.83,95%CI= 0. 72-0. 96,P=0. 011 ;GGq-GA vs AA,OR：0.86,95%CI=0.76-0.97,P：0. 017）. In the subgroup analysis of smok- ing status,ATM rs189307 AA could significantly increase the risk of lung cancer for non-smoking population （GG vs AA,OR：0.69,95%CI=0.56-0.86,P=0. 001 ;GG＋GA vs AA,OR=0.68,95 %CI=0.56-0.82,P=0. 000）. Conclu- sion ATM rs189307 AA may be a potential biomarker for lung cancer risk in Asian,particularly for non-smoking pop- ulation.

关 键 词：肺癌 ATM rs189307 多态性 吸烟 META分析 

分 类 号：R734.2[医药卫生—肿瘤]