鸦胆子油乳联合脑放疗治疗肺癌脑转移瘤的疗效及神经认知功能的影响  

CLINICAL RESEARCH OF STEREOTACTIC RADIOTHERAPY COMBINED WITH BRUCEA JAVANICA OIL ON BRAIN METASTASIS OF LUNG CANCER

作　　者：王晓红[1] 郑国红[1] 李义慧[2] 佟玲[3] 肖磊[2] 王建功[2] 杨俊泉[1] 

机构地区：[1]华北理工大学附属唐山市人民医院放化疗科,河北省唐山市063000 [2]华北理工大学附属唐山市人民医院生物治疗科 [3]华北理工大学附属唐山市人民医院药剂科

出　　处：《中国煤炭工业医学杂志》2016年第1期58-61,共4页Chinese Journal of Coal Industry Medicine

基　　金：河北省中医药管理局科研资助项目(编号:2013-121)

摘　　要：目的探讨鸦胆子油乳联合脑放疗治疗非小细胞肺癌脑转移瘤的临床疗效及神经认知功能的影响。方法回顾分析该科2011年10月—2014年10月收治鸦胆子油乳联合放疗治疗非小细胞肺癌脑转移瘤60例患者。放疗采用6MV-X线,放疗剂量DT40Gy/2Gy/20F,每周5次,鸦胆子油乳注射液30ml,放疗第一天开始至放疗结束,对照组58例予单纯放射治疗。结果治疗组与对照组之间的近期有效率差异有统计学意义(86.67%Vs 65.52%,P<0.05),并对二组治疗前后认知功能进行评定,治疗组在神经认知功能评分优于对照组差异有统计学意义(P<0.05)。结论鸦胆子油乳联合脑放疗治疗肺癌脑转移获得较好的近期有效率,改善非小细胞肺癌脑转移患者的神经认知功能,提高其生活质量。Objective To explore the efficacy and neurological function of stereotactic radiotherapy combined with Brucea javanica oil on brain metastasis of lung cancer.Methods From Oct.2011 to Oct.2013,a retrospective analysis was performed on patients with brain metastasis of lung cancer,treated with Brucea javanica oil emulsion combined with radiotherapy,60 cases were in study group and 58 cases of radiotherapy were in control group.Whole brain irradiation dose was 40Gy/2Gy/20 F in the study group,javanica oil emulsion injection 30 ml every day during radiotherapy,while the control group was radiotherapy.ResultsThe total efficiency of the stuey group was 86.67%,while the control group was 65.51%,the difference was statistically significant（P〉0.05）.Neurological function was significant different（P〈0.05）.Conclusion Radiotherapy combined with Brucea javanica oil is a efficacious methods in the treatment of brain metastasis of lung cancer.It can improve neurocognitive function and improve their quality of life.

关 键 词：非小细胞肺癌 脑转移瘤 鸦胆子油乳注射液 放射治疗 

分 类 号：R734.2[医药卫生—肿瘤]