嘌呤代谢异常与听力损失  

Abnormal Purine Metabolism and Hearing Loss

作　　者：王欣[1] 张璞[1] 张勋[1] 

机构地区：[1]河北医科大学第三医院耳鼻喉科,石家庄市050000

出　　处：《中华耳科学杂志》2015年第4期754-756,共3页Chinese Journal of Otology

摘　　要：嘌呤,是存在于人体内的一种化学成分,参与组成核酸及ATP等人体多种重要物质。嘌呤的代谢异常会引起一系列的疾病,包括:痛风、免疫系统疾病、血液疾病、肾脏疾病等,但目前其与耳聋的关系报道甚少,且多集中在遗传性耳聋方面。本文将对嘌呤代谢异常与耳聋的关系进行综述,并探讨嘌呤代谢异常引起非遗传性耳聋的发病机制。Purine, one chemical constituent existing in the human body, participates in the production of a variety of important substances including nucleic acids and ATP. Abnormal metabolism of purine leads to a series of diseases （e.g., gout, autoimmune diseases, blood diseases, kidney diseases, etc）. However, reports on the relationship between purine and hearing loss as hereditary deafness are rare. In this paper, we will summa- rize study evidence on the association between abnormal purine metabolism and hearing loss, and discuss the pathogenesis of non-hereditary deafness resulting from abnormal purine metabolism.

关 键 词：嘌呤 代谢异常 遗传性耳聋 非遗传性耳聋 

分 类 号：R764.43[医药卫生—耳鼻咽喉科]