p53、CerbB-2、ER、PR和Ki67在乳腺浸润性小叶癌的表达及临床意义  

Expressions and clinical significance of p53,CerbB-2,ER,PR and Ki67 in breast invasive lobular carcinoma

作　　者：陶曙[1] 邱志远[2] 雷珍[2] 许跃[3] 陆莉[4] 钟锡明[2] 范钰[2] 范磊 

机构地区：[1]江苏大学附属人民医院普通外科,212002 [2]江苏大学附属人民医院肿瘤科,212002 [3]江苏大学附属人民医院病理科,212002 [4]江苏大学附属人民医院乳腺外科,212002 [5]南京医科大学第一附属医院血液病科

出　　处：《江苏医药》2016年第3期266-268,共3页Jiangsu Medical Journal

基　　金：国家自然科学基金(81200360);江苏大学临床医学科技发展基金(JLY2010003)

摘　　要：目的探讨p53、CerbB-2、雌激素受体(ER)、孕激素受体(PR)和Ki67在乳腺浸润性小叶癌(ILC)的表达及临床意义。方法采用免疫组化方法检测27例ILC中p53、CerbB-2、ER、PR和Ki67的表达。结果 27例ILC患者的p53、CerbB-2、ER、PR和Ki67阳性率分别为33.3%、33.3%、77.8%、59.3%和70.4%。肿瘤直径≥3cm组的p53阳性率高于肿瘤直径<3cm组(P<0.05);有淋巴结转移组PR、Ki67和p53阳性率高于无淋巴结转移组(P<0.05)。p53、CerbB-2、ER、PR和Ki67表达与年龄、乳头侵犯和月经情况无相关性(P>0.05)。结论联合检测p53、CerbB-2、ER、PR和Ki67的表达有助于判断ILC的生物学行为,对指导治疗和判断预后有重要的意义。Objective To study the expressions and clinical significance of p53, CerbB-2, estrogen receptor（ER）, progestrone receptor（PR） and Ki67 in breast invasive lobular carcinoma （ILC）. Methods The expressions of p53, CerbB-2, ER, PR and Ki67 in breast ILC were detected by immunohistoehemistry. Results The positive rates of p53, CerbB-2, ER, PR and Ki67 in breast ILC of 27 patients were 33.3% ,33.3% ,77.8% ,59.3% and 70.4%,respectively. The positive rate of p53 in tumor size≥3 cm group was higher than that in tumor size≥3 cm group（P〈0. 05）. The positive rates of p53,PR and Ki67 were higher in the patients with lymph node metastasis than in those without （P〈0. 05）. The positive rates of p53, CerbPr2, ER, PR, Ki67 were not significantly associated with age,nipple invasion and menstruation status （P〉0. 05 ）. Conclusion Combined detection of the expressions of p53, CerhB-2, ER, PR and Ki67 is helpful to determine the biological behavior of breast ILC, which is of important significance in guiding the treatment and predicting the prognosis.

关 键 词：乳腺浸润性小叶癌 P53 CERBB-2 雌激素受体 孕激素受体 KI67 

分 类 号：R737[医药卫生—肿瘤]