探讨术前不同剂量抗生素对结肠癌根治术患者术后恢复的影响  

Influence of preoperative doses of antibiotics on postoperative recovery of colon cancer patients who accepted radical surgery

作　　者：梅迪[1] 刘洋[2] 胡枋[1] 马英杰[1] 申爽[2] 

机构地区：[1]葫芦岛市中心医院普外科,辽宁葫芦岛125000 [2]葫芦岛市中心医院检验科,辽宁葫芦岛125000

出　　处：《中国微生态学杂志》2016年第2期195-197,共3页Chinese Journal of Microecology

摘　　要：目的探讨术前不同剂量抗生素对结肠癌根治术患者术后恢复的影响。方法选取2013年4月至2015年5月在葫芦岛市中心医院普外行结肠癌根治术的99例患者,在基础肠道准备不变的情况下,按照术前服用抗生素的天数不同分为试验组51例,采取术前口服1天抗生素,即术前1天口服庆大霉素4mL+甲硝唑0.4g,日3次口服。对照组48例,术前2天口服庆大霉素4mL+甲硝唑0.4g,日3次口服。比较两组患者术后排气时间、切口感染、腹腔感染和腹泻人数等。结果试验组排气时间为(66.31±13.11)h,医疗费用(4.23±1.34)万元、切口感染率为1.96%,腹腔感染率为3.92%、腹泻率为5.89%,对照组排气时间为(90.31±13.12)h,医疗费用(4.92±1.41)万元、切口感染率为14.58%,腹腔感染率为18.75%、腹泻率为20.83%,组间比较差异有统计学意义(t=3.261、2.937,P<0.05;χ2=5.304、5.505、4.846,P<0.05),试验组优于对照组。结论对于结肠癌根治术的患者采用术前服用1天抗生素的模式,不仅降低医疗费用而且有助于术后恢复,减少感染的发生,值得在临床推广。Objective To explore the influence of preoperative doses of antibiotics on the postoperative recovery of patients who accepted radical surgery for colon cancer.Methods 99 patients with colon cancer in the general surgery department of Huludao Central Hospital were included.On the basis of regular bowel preparation,the patients were divided into two groups according to the preoperative dose of antibiotics.The 51 patients in the observation group were given gentamicin 4mL and metronidazole 0.4g t.i.d orally for one day prior to the surgery,while the 48 patients in the control group were given the same medication for two days before operation.The time to postoperative exhaust as well as the rates of,wound infection,abdominal infections and diarrhea were compared between the two groups.Results The indexes of the observation group were significantly superior than those of the control group（P〈0.05）.Conclusion The preoperative use of antibiotics for one day in patients with colon cancer can not only reduce medical expenses but also help the recovery of patients,and reduce the occurrence of infections.

关 键 词：抗生素 结肠癌根治术 肠道准备 

分 类 号：R735.3[医药卫生—肿瘤]