麦粒灸足三里、肺俞穴对化疗后非小细胞肺癌患者的中性粒-淋巴细胞比率及血小板数量的影响:随机对照研究  

Effect of scarring moxibustion at acupoints of Zusanli(ST36) and Feishu(BL13) on neutrophil-to-lymphocyte ratio and platelet count in patients with non-small-cell lung cancer after chemotherapy:a randomised controlled trial

作　　者：张梦雪[1] 关玲[1] 

机构地区：[1]解放军总医院针灸科,北京100853

出　　处：《中国临床医生杂志》2016年第1期42-45,共4页Chinese Journal For Clinicians

基　　金：国家自然科学基金(基金编号81273848)

摘　　要：目的探讨麦粒灸疗法对化疗后非小细胞肺癌患者中性粒-淋巴细胞比率及血小板数量的影响。方法将术后且完成化疗的非小细胞肺癌患者70例随机分为麦粒灸组和对照组各35例,麦粒灸组选取双侧足三里穴、双侧肺俞穴,每穴9壮,每日1次,对照组不进行任何干预治疗,只进行追踪随访,试验持续6周,观察治疗前后两组患者中性粒-淋巴细胞比率及血小板数量变化并比较两组的差异。结果麦粒灸组干预治疗后相较于治疗前,中性粒-淋巴细胞比率明显降低(P<0.001<0.05),血小板数量明显升高(P=0.023<0.05),对照组治疗前后中性粒-淋巴细胞比率(P=0.147>0.05)及血小板数量(P=0.254>0.05)差异均无显著性。治疗后两组组间比较,中性粒-淋巴细胞比率(P<0.001<0.05)及血小板数量(P=0.010<0.05)差异均有显著性。结论麦粒灸疗法能够降低非化疗后非小细胞肺癌患者的中性粒-淋巴细胞比率,提高血小板数量,从而改善患者的免疫功能及生活水平。Objective To evaluate the effect of scarring moxibustion on neutrophil-to-lymphocyte ratio（NLR） and platelet count in patients with non-small-cell lung cancer（NSCLC）.Method Seventy patients who suffers from NSCLC and have completed lobectomy and chemotherapy were randomised into two groups：moxibustion group received treatment of scarring moxibustion at the acupoints of Zusanli（ST36） and Feishu（BL13） and every acupoint got 9times every day for six weeks and control group received no treatment and were just followed up.Finally,33 patients in moxibustion group and 32 patients in control group completed the study and were analyzed.Outcome measures used in this study were neutrophil-to-lymphocyte ratio（NLR） and platelet count.The differences between the baseline and endpoint were observed and the effects of the two groups were compared.Result After the treatment,NLR in moxibustion group decreased significantly compared with baseline（P0.0010.05）,platelet count in moxibustion group increased significantly compared with baseline（P=0.0230.05）.In the control group,there were no significant differences between the baseline and endpoint in both NLR（P=0.1470.05） and platelet count（P=0.2540.05）.Between the two groups,there were significant differences in NLR（P0.0010.05） and platelet count（P=0.0100.05） after the treatment.Conclusion The present study suggests that scarring moxibustion treatment is effective to regulate the immunity by decreasing the NLR and increasing the platelet count in patients who suffers from NSCLC and have completed lobectomy and chemotherapy.

关 键 词：麦粒灸 非小细胞肺癌 炎症 粒淋比 血小板数量 

分 类 号：R734[医药卫生—肿瘤]