387例早产儿视网膜病变筛查情况及相关危险因素分析  

Screening of 387 Cases retinopathy of Prematurity and Risk Factor Analysis

作　　者：苏艳兰[1] 陈均[1] 欧小燕[1] 

机构地区：[1]茂名市妇幼保健院,广东茂名525500

出　　处：《中国伤残医学》2016年第1期12-14,共3页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的：探讨早产儿视网膜病变（ROP）的现患率及ROP相关危险因素。方法：对符合ROP筛查标准的387例早产儿进行筛查，根据筛查结果把早产儿分为ROP组（44例）和正常组（343例），统计2组ROP的严重程度，记录危险因素“早产儿性别”、“多胎妊娠”、“新生儿呼吸窘迫综合征”、“同步间歇指令通气”、“持续正压通气”、“1分钟apgar评分〈7分”、“5分钟apgar评分〈7分”、“10分钟apgar评分〈7分”、“抗感染治疗”、“光疗时间〉7天”、“胎膜早破”、“低血糖”、“高胆红素血症”、“钾低”、“缺血缺氧性脑病”、“输血”、“代谢性酸中毒”、“先天性心脏病”和“吸氧〉10天”的情况，采用Pearson卡方检验、Yates卡方和多因素logistic回归分析相关数据。结果：ROP的现患率为11．37％（44例）。独立危险因素“持续正压通气”、“抗感染治疗”、“吸氧〉10天”的Wald值分别为10．18、11．8和34．77，0R值分别为3．56（95％CI：1．63—7．78）、5．20（95％CI：2．03～13．32）、14．85（95％CI：5．06～36．42），P值均为0．00。结论：“CPAP”、“抗感染治疗”和“吸氧〉10天”是ROP的独立危险因素。Objective： Investigate the Screening result of ROP and assess the risk factors for ROP. Methods： Three hundred eighty - seven cases of premature infant were screeninged who meet the ROP screening criterion. According to the screening result, premature infant were divided into ROP group （44 cases） and normal group （343 cases）. The severity of ROP were be statisticsed, and risk factors ＂ gender of premature infant＂, ＂multiple pregnancy＂, ＂hyaline membrane disease of newborn＂, ＂ synchronized intermittent mandatory ven- tilation＂, ＂continuous positive pressure ventilation＂, ＂1 min apgar Score 〈7＂, ＂5 min apgar Score 〈7＂, ＂ 10 min apgar Score 〈7＂, ＂ anti - infective therapy＂, ＂the time of phototherapy 〉 7days＂, ＂ premature rupture of memberane＂, ＂ hypoglycaemia＂, ＂ hyperbilirubi- nemia＂, ＂hypothyroidism＂, ＂anoxic ischemic eneephalopathy＂, ＂blood transfusion＂, ＂metabolic acidosis＂, ＂congenital heart disease＂, ＂oxygen therapy 〉 10 days＂ were also be records. Using Pearson chi square test, Yates chi square test and Logistic Regression to analyze the data. Results： Prevalence rate of ROP was 11.37% （44 cases）. The Wald -value of ＂continuous positive pressure ventilation＂ , ＂ anti - infective therapy＂, ＂oxygen therapy 〉 10 days＂ were 10.18,11.8 and 34.77, OR - value of ＂continuous positive pressure ventila- tion＂ , ＂anti - infective therapy＂, ＂oxygen therapy 〉 10 days＂ were 3.56 （95% CI： 1.63 ~ 7.78 ） ,5.20 （95% C1：2.03 ~ 13.32）, 14. 85 （95 % C1：5.06 ~ 36.42）, and P - value of them were all 0.00. Conclusion： Continuous positive pressure ventilation, anti - infective therapy and oxygen therapy 〉 10 days were independent risk factors to ROP.

关 键 词：早产儿视网膜病变 危险因素 早产儿筛查 

分 类 号：R774.1[医药卫生—眼科]