不同放疗方案在肺癌脑转移患者中的应用效果  

Comparison of different radiotherapy methods of brain metastases of lung cancer

作　　者：肖创映[1] 韩光[1] 周晓艺[1] 徐姣珍[1] 谭文勇[1] 罗波[1] 胡德胜[1] 

机构地区：[1]湖北省肿瘤医院放疗中心,武汉430079

出　　处：《中国肿瘤临床与康复》2016年第1期14-16,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的比较同期推量放射治疗(SIB)和全脑照射+三维适形放射治疗(WBRT+3DCRT)序贯治疗在肺癌脑转移患者中的应用效果。方法收集2006年1月至2011年4月间152例患者行SIB(研究组),146例肺癌脑转移瘤患者行WBRT+3D-CRT序贯治疗(对照组),比较两组患者的临床效果。结果研究组患者的客观缓解率、疾病控制率和1年生存率均高于对照组,差异均有统计学意义(均P<0.05)。研究组患者中位无进展生存时间明显延长,与对照组差异有统计学意义(P<0.05)。结论 SIB能提高肺癌脑转移瘤患者的客观缓解率、疾病控制率和1年生存率,同时能延长中位生存时间。Objective To compare the application effect of simultaneous integrated boost intensitymodulated radiotherapy（ SIB） and whole brain irradiation ＋ three-dimensional conformal radiation therapy（ WBRT ＋ 3D-CRT） in the treatment for brain metastases of lung cancer. Methods From January 2006 to April 2011,the clinical data of brain metastases of lung cancer patients treatment with SIB（ study group,n = 152） and WBRT ＋ 3D-CRT（ control group,n = 146） were collected. The clinical efficacy between the two groups were compared. Results The objective response rate,disease control rate and 1-yr survival rate in the study group were higher than those of the control group,with significant differences（ χ~2= 10. 434,7. 61,25. 47; P〈0. 05）. The patients in the study group achieved longer median progression-free survival,and the difference was statistically significant（ t = 2. 53,P〈0. 05）. Conclusion SIB can increase objective response rate,disease control rate and 1-yr survival rate,and prolong median survival for lung cancer patients with brain metastases.

关 键 词：肺癌脑转移瘤 同期推量放射治疗 三维适形放疗 

分 类 号：R734.2[医药卫生—肿瘤]