TGF-β和E-cadherin在子宫颈鳞状细胞癌表达的临床意义  

The clinical significance of TGF-βand E-cadherin expression in cervical squamous cell carcinoma

作　　者：刘晨[1] 王莉[1] 张保莲[1] 王晓枫[2] 

机构地区：[1]武警北京总队医院妇产科,北京100027 [2]武警北京总队医院病理科,北京100027

出　　处：《中国妇产科临床杂志》2016年第1期14-17,共4页Chinese Journal of Clinical Obstetrics and Gynecology

摘　　要：目的探讨转化生长因子β(TGF-β)和上皮型钙黏蛋白(E-cadherin)在子宫颈鳞状细胞癌(cervical squamous cell carcinoma,CSCA)中的表达及与临床病理特征的关系。方法 60例CSCA患者的组织标本采用免疫组化方法检测其TGF-β和E-cadherin的表达,综合分析TGF-β和E-cadherin表达与肿瘤临床病理特征的关系。结果 CSCA浸润前沿TGF-β阳性表达增加,E-cadherin表达减弱。TGF-β在CSCA中表达水平与微血管密度、肿瘤大小、淋巴结转移和脉管内癌栓呈密切正相关;E-cadherin在CSCA中表达水平与细胞分化、淋巴结转移和脉管内癌栓呈密切负相关。Log-Rank分析显示:TGF-β高表达、E-cadherin低表达、脉管内癌栓、淋巴结转移、宫旁浸润与CSCA不良预后相关;多因素COX回归模型分析表明:TGF-β高表达、宫旁浸润、淋巴结转移是影响预后的独立因素。存在TGF-β高表达、宫旁浸润、淋巴结转移患者生存曲线显著下降。结论 CSCA患者TGF-β高表达、宫旁浸润和淋巴结转移预示不良预后。Objective To investigate the expression of TGF-βand E-cadherin and their relationship with clinical pathological features of cervical squamous cell carcinoma（CSCA）.Methods Sixty CSCA cases were enrolled in this study.The expression of TGF-βand E-cadherin was measured by immunohistochemistry.The clinical significance of TGF-βand E-cadherin expression was analyzed with clinical pathological features of CSCA.Results The expression of TGF-βwas increased significantly and the E-cadherin level reduced significantly in the invasive tumor front of CSCA.The expression of TGF-βin CSCA was positively correlated with microvessel density,tumor size,lymph node metastasis and vessel carcinoma embolus.The expression of E-cadherin in CSCA was negatively correlated with cell differentiation,lymph node metastasis and vessel carcinoma embolus.Log-Rank test indicated that up-regulation of TGF-β,down-regulation of E-cadherin,vessel carcinoma embolus,lymph node metastasis and parametrial infiltration was associated with poor prognosis of CSCA.COX regression multivariate analysis showed up-regulation of TGF-β,parametrial infiltration and lymph node metastasis is the independent factors affecting the prognosis.Moreover,up-regulation of TGF-β,parametrial infiltration and lymph node metastasis decreased the survival curve of CSCA patients significantly.Conclusion Up-regulation of TGF-β,parametrial infiltration and lymph node metastasis existed in CSCA patients indicates poor prognosis.

关 键 词：子宫颈鳞状细胞癌 上皮间质转换 转化生长因子Β 上皮型钙黏蛋白 预后 

分 类 号：R737.33[医药卫生—肿瘤]