靶向哺乳动物细胞线粒体的核酸转运  

Targeting delivery nucleic acid into mammalian mitochondria

作　　者：付爱玲[1] 

机构地区：[1]西南大学药学院,重庆400716

出　　处：《中国药理学通报》2016年第1期1-4,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81273416);教育部高校基本科研业务费(No XDJK2013A030);教育部回国人员启动基金;教育部新世纪优秀人才支持计划资助

摘　　要：线粒体DNA(mitochondrial DNA,mtDNA)的遗传性突变和缺陷是多种线粒体功能失调相关疾病的根本原因。靶向线粒体递送核酸,可从根本上纠正mtDNA突变、挽救mtDNA损伤、阻断疾病进程。哺乳细胞内线粒体的核酸转运途径与细胞核的基因转染大不相同。该文综述了向哺乳动物细胞线粒体递送DNA和RNA(tRNA、rRNA、mRNA和反义RNA)的有效策略,并对其存在问题和发展趋势做一阐述。Mitochondrial DNA( mt DNA) genome mutations and defects are the essential mechanism of a various of mitochondrial dysfunction associated with diseases. The studies of targeting delivery nucleic acid into mammalian mitochondria can thoroughly correct mt DNA mutation,rescue mt DNA impairment and then reverse the progress of diseases. There's obvious differences between nucleic acid import pathway of mammalian mitochondria and gene transfection of nuclei. In this paper,the effective strategies of delivering DNA and RNA( tRNA,rRNA,mRNA and antisense RNA) into mitochondria have been reviewed,as well as the challenges and development.

关 键 词：线粒体转导 靶向序列 核酸转运 线粒体相关疾病 tRNA载体 5srRNA转导 穿梭蛋白 

分 类 号：R-05[医药卫生] R329.24