齐拉西酮对首发精神分裂症患者眼动功能和执行功能的影响  

The Effect of Ziprasidone on Eye Movement Function and Executive Function of First-episode Schizophrenia

作　　者：孙志刚[1] 王斌[1] 薛曼[1] 宋丽华[1] 李素水[1] 王学义[2] 

机构地区：[1]河北省石家庄市第八医院精神五科,中国050000 [2]河北医科大学第一医院精神卫生科,河北医科大学精神卫生研究所,河北省脑老化与认知神经科学重点实验室

出　　处：《中国健康心理学杂志》2016年第2期167-171,共5页China Journal of Health Psychology

基　　金：河北省科技支撑计划重大项目(编号:09276103D);石家庄市科技研究与发展计划(编号:131460693)

摘　　要：目的:探讨齐拉西酮对首发精神分裂症患者眼动功能和执行功能的影响。方法:将79例首发精神分裂症患者随机分为齐拉西酮组(n=42)和利培酮组(n=37),在基线、治疗4周和8周时进行探究性眼球运动测试和威斯康星卡片分类测验(WCST)。结果:1眼动功能显示,治疗8周时两组的凝视点数显著提高(P<0.01);反应性探索评分(RSS分),两组在治疗4周、8周时均显著升高(P<0.01),而两组之间差异无统计学意义(P>0.05);D分值两组治疗4周时显著下降(P<0.01),治疗8周时平均降为负分;2WCST测验治疗前两组均存在执行功能障碍,两组间无统计学差异。与基线时相比,齐拉西酮组治疗4周、8周时总测验次数、持续错误数、随机错误数均明显降低(P均<0.01),正确反应数和分类完成数均明显提高(P均<0.01);利培酮组治疗4周、8周时总测验次数、持续错误数、随机错误数均明显降低(P均<0.01),正确反应数和分类完成数均明显提高(P均<0.01)。齐拉西酮组与利培酮组对比,治疗4周时随机错误数齐拉西酮组(29.70±10.66)较利培酮组(35.07±12.36)显著降低(t=2.06,P<0.05),治疗8周后齐拉西酮组(20.13±7.08)较利培酮组(23.26±6.28)显著降低(t=2.07,P<0.05);其余两组无显著性差异。结论:齐拉西酮对首发精神分裂症患者的眼球轨迹运动有显著影响,改善眼动功能,与对照组利培酮相比差异无统计学意义;首发精神分裂症患者存在执行功能受损,齐拉西酮对执行功能具有显著的改善,较利培酮效果显著;齐拉西酮是一种对认知功能有效的抗精神病药物,值得临床广泛应用与推广。Objective：To explore the effect of eye movement function and executive function of ziprasidone in the treatment of the first-episode schizophrenia.Methods：79first-episode schizophrenic inpatients were divided into Ziprasidone group（n=42）and Risperidone group（n=37）randomly in baseline,treated for 4weeks and 8 weeks.Meanwhile,exploratory eye movement（EEM）and wisconsin card sorting test（WCST）were used respectively.Results：1The results of EEM showed that ziprasidone and risperidone groups improved number of eye fixation（NEF）of thefirst-episode schizophrenic inpatients after 8weeks of treatment（P〈0.01）.The results of responsive search score（RSS）showed that ziprasidone and risperidone groups were significantly higher than baseline after 4 weeks and 8weeks of treatment（P〈0.01）,while there was no significant difference between ziprasidone and risperidone groups（P〉0.05）.The results of discriminant（D）showed that ziprasidone and risperidone groups were significantly lower than baseline after 4weeks of treatment（P〈0.01）,while ziprasidone and risperidone groups improved significantly（Down to negative scores）after 8weeks of treatment（P〈0.01）.（2）The results of wisconsin card sorting test（WCST）showed that the inpatient groups were both executive dysfunction and were not statistically significant.Compared with the baseline group,the total number of tests,the number of errors and random errors of schizophrenic inpatients decreased significantly after 4 weeks and 8 weeks of treatment with ziprasidone or risperidone（P〈0.01）,while number of correct responses and classifications increased significantly（P〈0.01）.However,the number of random errors of ziprasidone was lower than the number of random errors of risperidone after 4weeks of treatment（t=2.06,P〈0.05）.And the number of random errors of ziprasidone was lower than the number of random errors of risperidone after 8weeks of treatment（t=2.07,P〈0.05）.Conclusion：Ziprasidone can impact

关 键 词：首发精神分裂症 齐拉西酮 眼动功能 执行功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]