CD147和Survivin在肾细胞癌中的表达及临床病理分析  

Expression of CD147 and Survivin in renal cell carcinoma and their correlation with clinicopathologic parameters

作　　者：罗华荣[1] 柯莽[2] 周涛[1] 徐铖[1] 包卫光[3] 

机构地区：[1]温州医科大学附属台州医院病理科,浙江台州317000 [2]温州医科大学附属台州医院泌尿外科,浙江台州317000 [3]温州医科大学附属台州医院组织库,浙江台州317000

出　　处：《温州医科大学学报》2016年第1期56-60,共5页Journal of Wenzhou Medical University

摘　　要：目的：检测CD147和Survivin在人肾细胞癌组织中的表达,以探讨二者在肾细胞癌中表达的相关性及其与预后的关系。方法：利用组织芯片技术构建85例肾细胞癌与35例癌旁正常肾组织芯片,应用免疫组织化学Envision法检测CD147和Survivin在肾癌组织中的表达。结果：肾细胞癌组中CD147和Survivin的表达率分别为65.7%（23/35）和71.4%（25/35）,显著高于癌旁对照组（P〈0.01）。CD147在肾细胞癌中的表达随着肿瘤大小与病理分级的升高而升高（P〈0.05）;Survivin在肾细胞癌中的表达随着病理分级与临床分期的升高而升高（P〈0.05）。CD147和Survivin在肾细胞癌中的表达具有弱一致性（Kappa=0.388,P〈0.05）。Logistic回归分析显示Survivin的表达是肾细胞癌的独立危险因素（OR=16.256,95%CI：1.132~233.515,P〈0.05）。结论：CD147和Survivin在肾细胞癌中均有过量表达,可能参与了肾癌的发生发展过程,两者联合检测可用于评估肾细胞癌的恶性程度和预后。Objective： To investigate the expression of CD147 and Survivin in human renal cell carcinoma （RCC） and their correlation with clinicopathologic parameters. Methods： The RCC tissue microarrays containing 85 renal cell carcinoma specimens and 35 normal kidney tissue specimens were used to detect CD147 and Survivin expression by immunohistochemistry. Results： The expression rates of CD147 and Survivin were 65.7% （23/35） and 71.4% （25/35） in RCC group, respectively, significantly higher than that in control group （P〈0.01）. The expression of CD147 in RCC increased with the size of tumor and pathological grade （P〈0.05）. And the expression of Survivin in RCC increased with the pathological grade and clinical stage （P〈0.05）. The expression of CD147 and Survivin in RCC specimens showed weak consistency （Kappa=0.388, P〈0.05）. Multivariate logistic regression analysis showed that the positive expression of Survivin was an independent risk factor of RCC （OR=16.256, 95%CI： 1.132- 233.515, P〈0.05）. Conclusion： CD147 and Survivin are over-expressed in RCC specimens. CD 147 and Survivin may play a crucial stage in development of human RCC. Detection of the expression of CD147 and Sulvivin can be used in the evaluation of malignant degree and prognosis of RCC.

关 键 词：肾细胞癌 组织芯片 免疫组织化学 CD147 SURVIVIN 

分 类 号：R737.11[医药卫生—肿瘤]