急性缺血性脑卒中与乙醛脱氢酶2基因多态性的关系  

The Relationship of Acetaldehyde Dehydrogenase 2 Gene Polymorphism and Acute Ischemic Stroke

作　　者：靳美[1] 戴艳萍[1] 张春媛[1] 曹利[1] 宋培芸 

机构地区：[1]黑龙江省医院,哈尔滨150001

出　　处：《中国继续医学教育》2016年第2期39-40,共2页China Continuing Medical Education

摘　　要：目的探讨急性脑卒中与乙醛脱氢酶2基因多态性的相关性。方法选取自发性高血压大鼠、脑卒中倾向高血压大鼠进行研究,对照均选用京都种大鼠。利用荧光电泳法,比较组织蛋白的表达。应用乙醛脱氢酶2的激动剂和抑制剂分别观察神经元凋亡的情况。结果两组有42个差异蛋白点,乙醛脱氢酶2激动剂能够减轻缺氧缺糖诱导的神经元凋亡;乙醛脱氢酶2抑制剂促进缺氧缺糖诱导的神经元凋亡。结论乙醛脱氢酶2在急性缺血性脑卒中表达较低,增加乙醛脱氢酶2对神经有保护作用。Objective To investigate of acetaldehyde dehydrogenase 2 gene polymorphism and acute ischemic stroke.Methods Selected hypertensive rats with spontaneous hypertension and cerebral apoplexy for study,the control group adopt jingdu rat.The expression of tissue protein was compared with fluorescence method.The apoptosis was observed by used the agonist and inhibitor of aldehyde dehydrogenase 2.Results Two groups had 42 differential protein spots,and aldehyde dehydrogenase 2 agonists were able to reduce the apoptosis induced by hypoxia and glucose deprivation.Conclusion The expression of aldehyde dehydrogenase 2 in acute ischemic stroke is low,and the effect of aldehyde dehydrogenase 2 is increased protective nerve.

关 键 词：急性缺血性脑卒中 乙醛脱氢酶2 相关性 

分 类 号：R742[医药卫生—神经病学与精神病学]