P53、MDR-1基因在中老年食管癌患者中的表达及临床运用分析  

Expression and clinical application analysis of P53,MDR-1 gene in elderly patients with esophageal cancer

作　　者：钟亚莉[1] 刘超[1] 赵治国[1] 

机构地区：[1]河南省郑州大学第二附属医院消化内科,河南郑州450017

出　　处：《转化医学电子杂志》2016年第1期12-14,共3页E-Journal of Translational Medicine

摘　　要：目的:探究P53、MDR-1基因在中老年食管癌患者中的表达及临床意义.方法:选取郑州大学第二附属医院与安阳肿瘤医院共同收治的120例食管癌患者作为研究对象,对其血清P53基因,以及癌组织中P53蛋白及MDR-1基因进行检测,并对P53基因表达与患者放化疗预后的相关性进行分析.结果:P53基因mR NA阳性45例,表达量为0.43±0.12;阴性75例,表达量为0.09±0.03.P53 mR NA表达阳性组其MDR-1基因阳性例数为41例,阴性组其MDR-1基因的表达为65例;表达阴性组其治疗有效率明显高于阳性组,差异具有统计学意义(P<0.05).结论:P53、MDR-1基因的表达与食管癌患者治疗预后有明显的相关性.AIM： To explore the expression and clinical significance of P53,MDR-1 gene in elderly patients with esophageal cancer.METHODS： A total of 120 patients with esophageal cancer were selected as research objects.Their serum P53 gene were detected as well as the P53 protein and MDR-1 gene in cancer tissue.The correlation between P53 gene expression and prognosis after chemoradiotherapy in patients were analyzed.RESULTS： P53 gene mR NA-positive in 45 cases,with the expression level of 0.43± 0.12; 75 cases of negative expression,with the expression level of 0.09 ± 0.03; 41 MDR-1 gene positive cases in P53 mR NA-positive group,65 MDR-1 expression positive cases in P53 mR NA-negative group.Negative expression group had significantly higher efficiency of treatment（P〈0.05）.CONCLUSION： There is a significant interaction between expression of P53 and MDR-1 gene and prognosis of esophageal cancer patients.

关 键 词：P53基因 MDR-1基因 预后 食管癌 

分 类 号：R735.1[医药卫生—肿瘤]