老年牙周病患者感染病原菌的分布与相关因素分析  

Distribution of pathogens causing infections in elderly patients with periodontal disease and related factors

作　　者：彭澜[1] 刘中林[1] 王晖[1] 谢红帼 严加林[1] 

机构地区：[1]荆门市第一人民医院口腔科,湖北荆门448000

出　　处：《中华医院感染学杂志》2016年第4期900-901,904,共3页Chinese Journal of Nosocomiology

基　　金：湖北省卫生厅青年科技人才基金资助项目(QJX2012-15)

摘　　要：目的探讨老年牙周病患者感染病原菌的相关因素及其抗菌药物的应用效果。方法选取2013年1月-2014年1月医院收治的72例老年牙周病患者作为研究对象,设为观察组,对其病原菌进行检测,并根据检测结果给予抗菌药物治疗,观察治疗效果;另选同期进行健康体检的老年人96名作为对照组,对两组基本资料进行调查,分析患者感染病原菌分布及相关因素。结果观察组与对照组年龄差异无统计学意义,两组口腔卫生习惯、合并两种以上基础疾病、吸烟、文化程度、负面情绪、合并糖尿病等,差异均有统计学意义(P<0.05);72例患者共检测出111株病原菌,以伴放线放线菌(25.2%)、牙龈卟啉单细胞菌(19.8%)以及生痰二氧化碳嗜纤维菌(15.3%)的比例最高。替硝唑、奥硝唑对病原菌清除率分别为91.9%、94.6%,均高于甲硝唑的70.3%,差异有统计学意义(P<0.05)。结论老年牙周病患者感染病原菌的因素较多,养成良好的卫生习惯,定期进行牙周检查,及时治疗牙周病是避免牙丢失、保证口腔健康的有效方法。OBJECTIVE To explore the distribution of pathogens causing infections in elderly patients with periodontal disease,analyze the related factors,and observe the effect of use of antibiotics.METHODS A total of 72 elderly patients with periodontal disease who were treated in the hospital from Jan 2013 to Jan 2014 were recruited as the study objects and assigned as the observation group,then the pathogens were detected,the patients were treated with antibiotics on the basis of the detection results,and the therapeutic effect was observed.Meanwhile,96 healthy elderly people who received physical examination were chosen as the control group.The baseline data of the two groups of patients were investigated,the distribution of the pathogens causing the infections was observed,and the related factors for the infections were analyzed.RESULTS There was no significant difference in the age between the observation group and the control group;there was significant difference in the oral hygiene habit,complication with more than two kinds of underlying diseases,smoking,education level,negative emotion,or complication of diabetic mellitus between the two groups（P〈0.05）.Totally 111 strains of pathogens were isolated from 72 patients,of which 25.2% were Actinobacillus actinomy,19.8% were Porphyromonas gingivalis,and 15.3% were Capnocytophaga sputigena.The clearance rate of pathogens was 91.9% by tinidazole,94.6%by ornidazole,higher than 70.3% by metronidazole,and there was significant difference（P〈0.05）.CONCLUSION There are a variety of factors for the infections in the elderly patients with periodontal disease.It is an effective way to develop good health habit,regularly carry out the periodontal examination,and treat the periodontal disease in a timely manner so as to avoid the loss of teeth and ensure the oral health.

关 键 词：牙周病 老年 病原菌 抗菌药物 

分 类 号：R781.4[医药卫生—口腔医学]