肝组织弥散定量分析在脂肪肝诊断中的应用  

Quantitative analysis of tissue diffusion in diagnosing fatty liver

作　　者：金玲[1] 吴震中[2] 靳桂阳[1] 袁燕[1] 

机构地区：[1]南京军区杭州疗养院海勤疗养区超声科,杭州310002 [2]第二军医大学附属长征医院超声科

出　　处：《浙江医学》2015年第23期1928-1930,1957,共4页Zhejiang Medical Journal

摘　　要：目的探讨肝组织弥散定量分析在脂肪肝诊断中的应用价值。方法选择健康体检者1 30例,根据超声检查结果分为脂肪肝组(72例)和正常对照组(58例),进行肝组织弥散定量分析,得到12个定量参数,对比分析两组受试者各定量参数之间的关系,应用ROC曲线评价其诊断价值。结果脂肪肝组和正常对照组比较,除峰度、一致性和均等性3个参数无统计学差异外,其余参数如应变均值、标准偏差、蓝色区域百分比、复杂度、偏度、对比度、杂乱度、相关性和弹性定量值均有统计学差异(均P<0.01)。非条件Iogistic回归分析结果显示仅标准偏差和蓝色区域百分比进入回归方程,绘制ROC曲线,两者曲线下面积分别为0.866和0.887,选择51.500和15.685作为诊断脂肪肝的临界点,其灵敏度和特异度分别为95.8%和63.1%、93.1%和69.0%。结论肝组织弥散定量分析作为一种无创、定量的诊断技术,对于脂肪肝诊断具有一定的临床价值。Objective To investigate the value of quantitative analysis of tissue diffusion in diagnosis of fatty liver. Methods According to ultrasonic results, 130 subjects undergoing health check up were classified as fatty liver group （n=72） and control group （n=58）. Twelve quantitative parameters were measured by the quantitative analysis of tissue diffusion; the value of quantitative analysis in diagnosis of fatty liver was evaluated by using ROC curve. Results There were significant differences in quantitative parameters, including strain mean, standard deviation, percentage of blue area, complexity, skewness, contrast, clutter, correlation and elastic quantitative values between fatty liver and control groups （all P〈0.01）; but no significances in kurtosis, consistency and entropy（P 〉0.05）. Non-conditional logistic regression analysis showed that only standard deviation and blue area percentage entered in regression equation, and their area under the curve （AUC） of ROC were 0.866 and 0.887, respectively. Taking 51.500 and 15.685 as cut-off values, the sensibility and specificity of standard deviation and blue area percentage for diagnosis of fatty liver were 95.8% and 93.1%, 63.1% and 69.0%, respectively. Conclusion As a noninvasive and quantitative diagnostic technique, it is valuable to use quantitative analysis of tissue diffusion in diagnosis of fatty liver.

关 键 词：肝组织弥散定量分析 诊断 脂肪肝 

分 类 号：R575.5[医药卫生—消化系统]