中药内服联合熏洗治疗睑缘炎的临床观察  

Clinical observation of traditional Chinese medicine combined with steaming-washing therapy on blepharitis

作　　者：罗燕[1] 马珊[1] 刘楚玉[1] 杨金润[1] 王彦[1] 陈辰[1] 

机构地区：[1]云南中医学院第一附属医院,昆明650021

出　　处：《中国中医眼科杂志》2015年第6期416-420,共5页China Journal of Chinese Ophthalmology

基　　金：云南中医学院科学研究基金项目(XK201305)

摘　　要：目的观察中药内服联合熏洗治疗睑缘炎的有效性和安全性。方法将符合纳入标准的睑缘炎患者60例随机分为2组,试验组30例,对照组30例。试验组辨证采用自拟桑菊荆防汤、五味消毒饮加减方、导赤散加减方,内服加熏洗治疗,每日1剂,每日2次。对照组采用红霉素眼膏涂布睑缘治疗,每晚1次,同时给予妥布霉素滴眼液点眼,每日3次治疗。2组均治疗28 d,在治疗开始日及第7、14、28天4个时间点观察各组患者睑缘炎的症状、体征的变化以及在治疗过程中出现的药物不良反应,双眼病例取病情严重眼统计。结果 1.睑缘炎评分:2组治疗后各时间点的睑缘炎评分逐渐降低,组内两两比较差异均有统计学意义(P<0.01)。组间比较显示,治疗后28 d时,试验组总评分明显低于对照组,其余各时间点2组评分接近(P>0.05)。2.疗效评价:治疗后7 d,试验组痊愈0例,显效1例,好转27例,无效2例,有效率93.3%;对照组痊愈0例,显效0例,好转19例,无效11例,有效率63.3%(Z=-5.517,P<0.001)。治疗后14 d,试验组痊愈0例,显效11例,好转17例,无效2例,有效率93.3%;对照组痊愈0例,显效2例,好转23例,无效5例,有效率83.3%(Z=-4.053,P<0.001)。治疗后28 d,试验组痊愈4例,显效23例,好转3例,无效0例,有效率100.0%;对照组痊愈0例,显效8例,好转18例,无效4例,有效率86.7%(Z=-7.832,P<0.001)。试验组和对照组均未见不良反应发生。结论辨证使用中药内服联合熏洗可以有效地改善睑缘炎患者的症状和体征,是治疗睑缘炎的一种安全、有效的方法。OBJECTIVE To observe the efficacy and safety of traditional Chinese medicine combined with steaming and washing therapy on blepharitis. METHODS Sixty patients of blepharitis were randomly divided into treatment group of 30 patients and control group of 30 cases. Differentiation of symptom and signs was used in the experiment group to decide prescription in self-made Sangju Jingfang decoction, Wuwei Xiaodu decoction,Daochisan decoction with modifications orally orally plus steaming treatment 2 times a day. The other group was treated with erythromycin eye ointment coating blephatitis treatment, once a day, in addition to tobramucin eye drops daily 3 times. Two groups were treated for 28 days, at the start of treatment, and the 7th, 14 thand 28thdays observed patients in each group for changes in blepharitis symptoms and signs as well as side effects. For patients with both eyes involved, the worse one was chose as subject. RESULTS 1. Blepharitis score： after treatment,blepharitis score of the two groups decreased gradually at each time point, groups in pairwise comparisons showed that the difference was statistically significant（P〈0.01）. The total score of the experimental group was significantly lower than that of the control group at 28 d after treatment, but score of 2 groups at other time points were close to each other（P〉0.05）.2 Evaluation： For experiment group, 7 d after treatment, 0 cases were cured, 1 cases was markedly effective, 27 cases improved; for control group, 2 cases were ineffective, 93.3% cases were effective; in control group, 0 cases werecured, 0 cases were cured, 19 cases were effective, 11 cases were ineffective, 63.3% cases were effective,63.3%（P〈0.001, Z=-5.517）. After treatment, for experiment group at 14 d, 0 cases were cured, 11 caseswere markedly effective, 17 cases improved, 93.3% cases was effective; for control group, 0 cases were cured, 2 cases were cured, 23 cases were effective, 5 cases were ineffective, 83.3% cases were effective（P〈0.001, Z=-4.053）. A

关 键 词：睑缘炎 辨证论治 中医药疗法 

分 类 号：R777.1[医药卫生—眼科]